Setting description

Equal randomization: several treatments more effective in distinctive signatures (cfr scen 7)

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
—+ param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
–+- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
–++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
-+– param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+-+ param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-++- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+— param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
+–+ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
+-+- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
+-++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
++– param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++-+ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+++- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.129, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.098, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 7.6, median = 5.5 mean = 9.9, median = 7.1 mean = 10, median = 7.2 mean = 10, median = 7.2
effect af = 1, hr = 1 af = 0.87, hr = 1.16 af = 1.13, hr = 0.88 af = 1.14, hr = 0.87 af = 1.14, hr = 0.87
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.098, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 9.9, median = 7.1 mean = 10, median = 7.2 mean = 10, median = 7.2
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 1.13, hr = 0.88 af = 1.14, hr = 0.87 af = 1.14, hr = 0.87
TP53+ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.098, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 9.9, median = 7.1 mean = 10, median = 7.2 mean = 10, median = 7.2
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 1.13, hr = 0.88 af = 1.14, hr = 0.87 af = 1.14, hr = 0.87
DRD+ param scale = 0.112, shape = 1.05 scale = 0.129, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 7.6, median = 5.5 mean = 9.9, median = 7.1 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.87, hr = 1.16 af = 1.13, hr = 0.88 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.129, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.098, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 7.6, median = 5.5 mean = 25, median = 18 mean = 10, median = 7.2 mean = 10, median = 7.2
effect af = 1, hr = 1 af = 0.87, hr = 1.16 af = 2.85, hr = 0.33 af = 1.14, hr = 0.87 af = 1.14, hr = 0.87

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 3 3 0 1
TP53- & AR- 272 5 2 2
TP53+ 1 12 3 4
DRD+ 0 3 166 159
TEfus+ 1 167 1 3
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.006 0.006 0.000 0.002
TP53- & AR- 0.544 0.010 0.004 0.004
TP53+ 0.002 0.024 0.006 0.008
DRD+ 0.000 0.006 0.332 0.318
TEfus+ 0.002 0.334 0.002 0.006
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 1 0 0 0
TP53- & AR- 0 105 122 110
TP53+ 254 0 3 3
DRD+ 75 7 0 0
TEfus+ 93 0 6 11
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.002 0.000 0.000 0.000
TP53- & AR- 0.000 0.210 0.244 0.220
TP53+ 0.508 0.000 0.006 0.006
DRD+ 0.150 0.014 0.000 0.000
TEfus+ 0.186 0.000 0.012 0.022
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 8 11 14 17
TP53+ 1 9 14 13
DRD+ 0 0 0 0
TEfus+ 0 1 0 2
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.016 0.022 0.028 0.034
TP53+ 0.002 0.018 0.028 0.026
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.002 0.000 0.004


Errors & power

The overall error was 0.048.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.008             0.026             0.006             0.008 

The overall power was 0.858.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.544             0.334             0.332             0.318 

Median results at the end of the trial

By signature:
signature var Carboplatin Control Hormone_therapies Niraparib Taxel_therapies
all graduation 0 0 3 1 3
futility 0 0 1 0 0
max_n 0 0 0 0 0
n 248 (180, 292) 276 (244, 311) 186 (121, 253) 244 (182, 292) 236 (177, 287)
n_unique 225 (164, 266) 252 (226, 284) 167 (106, 230) 221 (165, 268) 216 (160, 262)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) NA (NA, NA) 4 (4, 4) 5 (5, 5) 4 (4, 5)
post_p 0.24 (0.01, 0.71) NA (NA, NA) 0.47 (0.02, 0.98) 0.23 (0.01, 0.71) 0.53 (0.06, 0.94)
rate 0.1 (0.09, 0.115) 0.093 (0.084, 0.102) 0.092 (0.075, 0.115) 0.101 (0.09, 0.114) 0.092 (0.079, 0.109)
DRD+ graduation 166 0 0 159 3
futility 0 0 75 0 7
max_n 0 0 0 0 0
n 67 (28, 90) 82 (67, 99) 52 (31, 77) 67 (30, 89) 68 (45, 93)
n_unique 60 (25, 81) 76 (61, 92) 46 (27, 71) 61 (27, 80) 60 (40, 83)
time_trial 36 (16, 36) 36 (36, 36) 36 (22, 36) 36 (16, 36) 36 (36, 36)
time_stop 20 (12, 32) NA (NA, NA) 20 (14, 32) 20 (13, 32) 17 (13, 33)
post_p 1 (0.99, 1) NA (NA, NA) 0.15 (0.01, 0.64) 1 (0.99, 1) 0.52 (0.12, 0.92)
rate 0.036 (0.027, 0.044) 0.089 (0.074, 0.107) 0.099 (0.076, 0.135) 0.035 (0.027, 0.044) 0.079 (0.061, 0.1)
TEfus+ graduation 1 0 1 3 167
futility 6 0 93 11 0
max_n 0 0 0 2 1
n 94 (69, 119) 105 (87, 124) 70 (36, 101) 91 (69, 118) 86 (28, 114)
n_unique 85 (63, 107) 96 (80, 114) 63 (32, 89) 83 (62, 107) 77 (25, 101)
time_trial 36 (36, 36) 36 (36, 36) 36 (22, 36) 36 (36, 36) 36 (12, 36)
time_stop 13 (12, 26) NA (NA, NA) 22 (11, 35) 16 (9, 24) 15 (10, 31)
post_p 0.16 (0.01, 0.55) NA (NA, NA) 0.02 (0, 0.23) 0.17 (0.02, 0.55) 1 (0.98, 1)
rate 0.09 (0.073, 0.109) 0.074 (0.063, 0.086) 0.11 (0.086, 0.139) 0.088 (0.073, 0.107) 0.038 (0.03, 0.046)
TP53- & AR- graduation 2 0 272 2 5
futility 122 0 0 110 105
max_n 14 0 8 17 11
n 100 (30, 130) 115 (96, 143) 73 (26, 116) 100 (31, 129) 100 (32, 131)
n_unique 92 (28, 117) 106 (88, 133) 68 (24, 106) 91 (28, 118) 92 (29, 120)
time_trial 36 (12, 36) 36 (36, 36) 29 (9, 36) 36 (12, 36) 36 (13, 36)
time_stop 13 (9, 23) NA (NA, NA) 12 (9, 28) 13 (9, 21) 13 (9, 23)
post_p 0.02 (0, 0.24) NA (NA, NA) 1 (0.93, 1) 0.02 (0, 0.2) 0.02 (0, 0.2)
rate 0.106 (0.088, 0.128) 0.073 (0.062, 0.085) 0.042 (0.034, 0.051) 0.105 (0.09, 0.13) 0.109 (0.09, 0.134)
TP53+ graduation 3 0 1 4 12
futility 3 0 254 3 0
max_n 14 0 1 13 9
n 114 (90, 137) 119 (103, 138) 89 (33, 119) 113 (91, 136) 108 (78, 133)
n_unique 104 (82, 124) 108 (93, 127) 81 (30, 108) 102 (82, 124) 97 (72, 120)
time_trial 36 (36, 36) 36 (36, 36) 35 (12, 36) 36 (36, 36) 36 (36, 36)
time_stop 12 (10, 18) NA (NA, NA) 18 (10, 32) 11 (9, 14) 11 (8, 16)
post_p 0.7 (0.22, 0.97) NA (NA, NA) 0.02 (0, 0.13) 0.69 (0.22, 0.97) 0.96 (0.63, 1)
rate 0.103 (0.088, 0.12) 0.112 (0.098, 0.129) 0.162 (0.138, 0.194) 0.103 (0.088, 0.123) 0.084 (0.069, 0.105)


By subgroup combinations:
subtype var Carboplatin Control Hormone_therapies Niraparib Taxel_therapies
—- graduation 124 0 276 113 113
futility 0 0 0 0 0
max_n 14 0 8 17 11
n 62 (19, 81) 70 (55, 88) 47 (16, 72) 63 (20, 81) 62 (22, 83)
n_unique 58 (18, 76) 64 (50, 84) 44 (15, 68) 59 (19, 75) 58 (21, 78)
post_p 0 (0, 0.06) NA (NA, NA) 1 (0.96, 1) 0 (0, 0.05) 0 (0, 0.06)
rate 0.158 (0.132, 0.193) 0.083 (0.067, 0.101) 0.043 (0.032, 0.056) 0.161 (0.135, 0.191) 0.158 (0.132, 0.193)
—+ graduation 128 0 343 122 256
futility 0 0 0 0 0
max_n 14 0 8 17 12
n 14 (4, 20) 15 (10, 22) 7 (2, 17) 13 (4, 21) 10 (2, 18)
n_unique 12 (3, 18) 14 (9, 20) 6 (2, 15) 12 (4, 19) 9 (2, 17)
post_p 0.04 (0, 0.23) NA (NA, NA) 0.75 (0.41, 0.96) 0.05 (0, 0.25) 0.83 (0.43, 0.97)
rate 0.161 (0.109, 0.266) 0.051 (0.03, 0.081) 0.044 (0.021, 0.08) 0.159 (0.105, 0.261) 0.038 (0.02, 0.075)
–+- graduation 6 0 259 8 15
futility 0 0 0 0 0
max_n 14 0 1 13 9
n 37 (28, 46) 38 (29, 46) 29 (10, 41) 38 (28, 47) 37 (28, 46)
n_unique 34 (26, 43) 34 (26, 43) 27 (10, 37) 34 (26, 43) 34 (25, 42)
post_p 0.4 (0.07, 0.82) NA (NA, NA) 0.4 (0.09, 0.78) 0.37 (0.07, 0.8) 0.38 (0.07, 0.79)
rate 0.159 (0.128, 0.206) 0.146 (0.115, 0.181) 0.163 (0.127, 0.224) 0.163 (0.128, 0.206) 0.161 (0.129, 0.202)
–++ graduation 12 0 305 22 177
futility 0 0 0 0 0
max_n 14 0 1 14 10
n 27 (19, 35) 26 (19, 34) 18 (7, 30) 26 (18, 34) 22 (8, 31)
n_unique 24 (17, 33) 24 (17, 32) 16 (6, 27) 24 (17, 31) 20 (7, 28)
post_p 0.05 (0, 0.27) NA (NA, NA) 0.08 (0.01, 0.32) 0.06 (0, 0.27) 0.99 (0.9, 1)
rate 0.156 (0.121, 0.201) 0.085 (0.059, 0.122) 0.161 (0.12, 0.23) 0.158 (0.119, 0.206) 0.039 (0.022, 0.055)
-+– graduation 252 0 328 249 122
futility 0 0 0 0 0
max_n 11 0 8 17 11
n 10 (3, 18) 15 (9, 21) 7 (2, 17) 10 (3, 19) 13 (4, 20)
n_unique 9 (3, 16) 14 (8, 20) 6 (2, 15) 10 (3, 17) 12 (4, 18)
post_p 0.86 (0.51, 0.98) NA (NA, NA) 0.77 (0.43, 0.93) 0.85 (0.53, 0.98) 0.05 (0, 0.26)
rate 0.035 (0.018, 0.069) 0.08 (0.053, 0.125) 0.043 (0.021, 0.081) 0.037 (0.02, 0.067) 0.162 (0.104, 0.228)
-+-+ graduation 255 0 376 255 262
futility 0 0 0 0 0
max_n 11 0 8 17 12
n 10 (3, 21) 16 (10, 23) 6 (2, 18) 11 (3, 20) 10 (3, 20)
n_unique 9 (3, 18) 15 (9, 21) 5 (2, 15) 10 (3, 18) 9 (2, 18)
post_p 0.63 (0.28, 0.88) NA (NA, NA) 0.55 (0.25, 0.81) 0.63 (0.3, 0.88) 0.58 (0.26, 0.88)
rate 0.037 (0.018, 0.066) 0.053 (0.032, 0.079) 0.042 (0.018, 0.079) 0.036 (0.018, 0.064) 0.039 (0.018, 0.069)
-++- graduation 170 0 294 164 25
futility 0 0 0 0 0
max_n 14 0 1 11 9
n 7 (3, 11) 8 (4, 12) 5 (2, 11) 7 (3, 12) 8 (4, 13)
n_unique 6 (2, 11) 7 (4, 11) 5 (1, 10) 6 (2, 11) 7 (3, 11)
post_p 0.93 (0.69, 0.99) NA (NA, NA) 0.28 (0.09, 0.55) 0.92 (0.69, 0.99) 0.25 (0.04, 0.53)
rate 0.034 (0.013, 0.07) 0.151 (0.087, 0.267) 0.168 (0.101, 0.36) 0.035 (0.015, 0.071) 0.167 (0.094, 0.283)
-+++ graduation 175 0 329 175 184
futility 0 0 0 0 0
max_n 14 0 1 12 10
n 7 (3, 12) 9 (5, 13) 5 (1, 10) 7 (2, 12) 7 (2, 12)
n_unique 6 (2, 11) 8 (5, 13) 4 (1, 9) 6 (2, 11) 6 (2, 11)
post_p 0.76 (0.46, 0.93) NA (NA, NA) 0.16 (0.03, 0.38) 0.76 (0.45, 0.94) 0.73 (0.46, 0.93)
rate 0.034 (0.013, 0.072) 0.087 (0.044, 0.158) 0.164 (0.097, 0.378) 0.035 (0.013, 0.078) 0.038 (0.015, 0.077)
+— graduation 0 0 4 1 3
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 12 (8, 17) 12 (7, 17) 12 (7, 16) 12 (8, 17) 12 (8, 17)
n_unique 11 (7, 15) 11 (6, 15) 10 (6, 15) 11 (7, 16) 11 (7, 16)
post_p 0.47 (0.14, 0.82) NA (NA, NA) 0.42 (0.12, 0.81) 0.46 (0.12, 0.8) 0.47 (0.12, 0.84)
rate 0.155 (0.104, 0.24) 0.145 (0.093, 0.222) 0.166 (0.112, 0.257) 0.161 (0.11, 0.252) 0.16 (0.106, 0.254)
+–+ graduation 7 0 98 15 170
futility 0 0 0 0 0
max_n 0 0 0 2 1
n 10 (6, 15) 10 (6, 15) 9 (4, 15) 10 (6, 14) 8 (3, 14)
n_unique 9 (5, 14) 9 (6, 14) 8 (4, 13) 9 (5, 13) 7 (2, 12)
post_p 0.2 (0.03, 0.51) NA (NA, NA) 0.21 (0.04, 0.53) 0.2 (0.04, 0.52) 0.94 (0.67, 1)
rate 0.163 (0.106, 0.255) 0.087 (0.048, 0.153) 0.166 (0.102, 0.278) 0.168 (0.107, 0.267) 0.038 (0.017, 0.076)
+-+- graduation 6 0 259 8 15
futility 0 0 0 0 0
max_n 14 0 1 13 9
n 10 (6, 15) 10 (6, 15) 8 (2, 13) 10 (5, 14) 10 (6, 14)
n_unique 9 (5, 13) 9 (5, 13) 6 (2, 11) 9 (5, 13) 9 (5, 13)
post_p 0.46 (0.15, 0.8) NA (NA, NA) 0.42 (0.17, 0.76) 0.47 (0.16, 0.81) 0.48 (0.16, 0.81)
rate 0.16 (0.105, 0.268) 0.151 (0.095, 0.236) 0.175 (0.115, 0.34) 0.16 (0.107, 0.261) 0.157 (0.104, 0.249)
+-++ graduation 12 0 305 22 177
futility 0 0 0 0 0
max_n 14 0 1 14 10
n 11 (7, 16) 11 (7, 16) 7 (2, 12) 10 (6, 16) 8 (3, 14)
n_unique 10 (6, 14) 10 (6, 14) 6 (2, 12) 9 (5, 14) 7 (2, 13)
post_p 0.19 (0.04, 0.49) NA (NA, NA) 0.24 (0.06, 0.5) 0.19 (0.04, 0.49) 0.94 (0.66, 0.99)
rate 0.16 (0.109, 0.253) 0.087 (0.05, 0.152) 0.173 (0.107, 0.336) 0.164 (0.107, 0.262) 0.039 (0.018, 0.078)
++– graduation 166 0 79 160 13
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 6 (3, 11) 8 (5, 12) 7 (4, 12) 6 (3, 11) 8 (4, 12)
n_unique 6 (2, 10) 7 (4, 11) 7 (3, 11) 6 (2, 10) 7 (4, 11)
post_p 0.92 (0.67, 0.99) NA (NA, NA) 0.24 (0.07, 0.5) 0.91 (0.69, 0.99) 0.24 (0.07, 0.57)
rate 0.035 (0.013, 0.077) 0.152 (0.09, 0.261) 0.167 (0.1, 0.311) 0.036 (0.015, 0.073) 0.158 (0.095, 0.293)
++-+ graduation 172 0 147 171 177
futility 0 0 0 0 0
max_n 0 0 0 2 1
n 7 (2, 11) 8 (5, 13) 7 (3, 11) 7 (2, 12) 7 (2, 12)
n_unique 6 (2, 10) 8 (4, 12) 6 (2, 10) 6 (2, 11) 6 (2, 11)
post_p 0.76 (0.48, 0.94) NA (NA, NA) 0.13 (0.02, 0.34) 0.78 (0.45, 0.94) 0.76 (0.44, 0.93)
rate 0.035 (0.014, 0.069) 0.089 (0.044, 0.169) 0.166 (0.099, 0.304) 0.036 (0.014, 0.073) 0.037 (0.017, 0.08)
+++- graduation 170 0 294 164 25
futility 0 0 0 0 0
max_n 14 0 1 11 9
n 7 (3, 11) 8 (5, 13) 5 (2, 10) 7 (3, 12) 8 (4, 13)
n_unique 6 (2, 10) 8 (4, 12) 5 (1, 9) 6 (2, 11) 7 (3, 11)
post_p 0.92 (0.69, 0.99) NA (NA, NA) 0.27 (0.09, 0.53) 0.93 (0.72, 0.99) 0.24 (0.06, 0.58)
rate 0.035 (0.015, 0.069) 0.153 (0.088, 0.265) 0.173 (0.101, 0.343) 0.034 (0.012, 0.069) 0.159 (0.096, 0.268)
++++ graduation 175 0 329 175 184
futility 0 0 0 0 0
max_n 14 0 1 12 10
n 7 (3, 13) 9 (5, 13) 5 (2, 10) 7 (3, 12) 7 (2, 12)
n_unique 6 (2, 11) 8 (4, 12) 5 (1, 9) 6 (2, 11) 6 (2, 11)
post_p 0.78 (0.46, 0.95) NA (NA, NA) 0.17 (0.03, 0.36) 0.78 (0.46, 0.95) 0.75 (0.44, 0.93)
rate 0.034 (0.013, 0.074) 0.094 (0.047, 0.181) 0.173 (0.093, 0.373) 0.034 (0.013, 0.069) 0.04 (0.015, 0.078)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Niraparib Carboplatin
all count 3 3 1
time_stop 4 (4, 4) 4 (4, 5) 5 (5, 5)
n_trt 28 (26, 29) 27 (25, 32) 33 (33, 33)
n_control 24 (22, 30) 24 (17, 35) 23 (23, 23)
post_p 0.9 (0.86, 0.91) 0.97 (0.92, 0.97) 0.9 (0.9, 0.9)
order 1 (1, 1) 1 (1, 1) 1 (1, 1)
TP53- & AR- count 272 5 2 2
time_stop 12 (9, 28) 11 (8, 12) 12 (12, 13) 9 (8, 10)
n_trt 30 (25, 81) 28 (25, 34) 38 (36, 40) 26 (25, 28)
n_control 33 (20, 81) 27 (25, 31) 34 (32, 36) 22 (20, 24)
post_p 0.98 (0.91, 1) 0.88 (0.86, 0.9) 0.91 (0.88, 0.93) 0.95 (0.95, 0.96)
order 1 (1, 2) 1 (1, 1.6) 1.5 (1.1, 1.9) 1 (1, 1)
TP53+ count 1 12 4 3
time_stop 7 (7, 7) 11 (8, 16) 12 (10, 14) 11 (9, 18)
n_trt 25 (25, 25) 32 (25, 52) 34 (25, 43) 28 (26, 43)
n_control 17 (17, 17) 37 (19, 55) 30 (22, 36) 30 (27, 56)
post_p 0.86 (0.86, 0.86) 0.98 (0.9, 0.99) 0.94 (0.87, 0.98) 0.93 (0.91, 0.98)
order 1 (1, 1) 1 (1, 2) 2 (1.3, 2) 1 (1, 1.8)
DRD+ count 3 159 166
time_stop 13 (11, 14) 20 (13, 32) 20 (12, 32)
n_trt 25 (25, 27) 38 (26, 73) 34 (25, 71)
n_control 18 (16, 24) 39 (22, 74) 38 (23, 72)
post_p 0.92 (0.9, 0.96) 1 (0.97, 1) 1 (0.96, 1)
order 2 (1.2, 2) 2 (1, 3) 2 (1, 3)
TEfus+ count 1 167 3 1
time_stop 10 (10, 10) 15 (10, 31) 9 (7, 12) 14 (14, 14)
n_trt 25 (25, 25) 34 (26, 85) 25 (25, 33) 29 (29, 29)
n_control 19 (19, 19) 36 (22, 86) 29 (20, 31) 41 (41, 41)
post_p 0.97 (0.97, 0.97) 0.99 (0.96, 1) 0.94 (0.88, 0.96) 0.99 (0.99, 0.99)
order 1 (1, 1) 1 (1, 3) 1 (1, 1) 2 (2, 2)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 1
time_stop 4 (4, 4)
n_trt 30 (30, 30)
n_control 22 (22, 22)
post_p 0.14 (0.14, 0.14)
order 1 (1, 1)
TP53- & AR- count 105 122 110
time_stop 14 (9, 24) 13 (9, 23) 13 (9, 21)
n_trt 36 (26, 70) 32 (26, 67) 32 (25, 61)
n_control 37 (23, 71) 34 (21, 73) 32 (20, 59)
post_p 0.04 (0, 0.17) 0.07 (0.01, 0.24) 0.06 (0.01, 0.24)
order 1 (1, 2) 1 (1, 2) 1 (1, 2)
TP53+ count 254 3 3
time_stop 18 (10, 32) 13 (12, 15) 11 (9, 13)
n_trt 56 (28, 99) 39 (39, 41) 38 (29, 39)
n_control 54 (25, 99) 43 (39, 47) 31 (29, 33)
post_p 0.02 (0, 0.13) 0.03 (0.03, 0.11) 0.06 (0.06, 0.24)
order 1 (1, 3) 2 (1.2, 2) 1 (1, 1.8)
DRD+ count 75 7
time_stop 20 (14, 32) 18 (16, 33)
n_trt 33 (26, 51) 33 (30, 84)
n_control 40 (23, 62) 35 (26, 73)
post_p 0.03 (0, 0.13) 0.07 (0.03, 0.13)
order 2 (1, 3) 2 (1, 3)
TEfus+ count 93 6 11
time_stop 22 (11, 35) 12 (12, 28) 19 (10, 25)
n_trt 47 (26, 83) 34 (29, 77) 39 (25, 54)
n_control 54 (24, 102) 33 (26, 75) 45 (23, 72)
post_p 0.01 (0, 0.06) 0.02 (0, 0.09) 0.04 (0.02, 0.09)
order 2 (1, 3.8) 3 (1.5, 3) 2 (1, 4)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
time 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4)
n 8 (6, 10) 1 (0, 1) 4 (3, 5) 3 (2, 3) 1 (0, 1) 4 (2, 5) 0 (0, 2) 0 (0, 2) 1 (0, 3) 1 (1, 3) 0 (0, 0) 0 (0, 1) 1 (0, 2) 1 (0, 3) 1 (1, 1) 0 (0, 1)
post_p 0.73 (0.68, 0.74) 0.5 (0.5, 0.5) 0.67 (0.6, 0.73) 0.6 (0.57, 0.66) 0.57 (0.54, 0.59) 0.52 (0.52, 0.52) 0.5 (0.5, 0.5) 0.58 (0.58, 0.58) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.61 (0.61, 0.61) 0.64 (0.64, 0.64) 0.56 (0.56, 0.56) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0 (0, 0.073) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.059 (0.012, 0.106) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.051 (0.01, 0.092) 0 (0, 1.248) 0.291 (0.291, 0.291)
Niraparib count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5)
n 8 (8, 8) 1 (1, 1) 4 (4, 4) 2 (2, 2) 2 (2, 2) 2 (2, 2) 2 (2, 2) 2 (2, 2) 2 (2, 2) 1 (1, 1) 1 (1, 1) 0 (0, 0) 0 (0, 0) 2 (2, 2) 2 (2, 2) 2 (2, 2)
post_p 0.67 (0.67, 0.67) 0.68 (0.68, 0.68) 0.57 (0.57, 0.57) 0.58 (0.58, 0.58) 0.55 (0.55, 0.55) 0.5 (0.5, 0.5) 0.52 (0.52, 0.52) 0.52 (0.52, 0.52) 0.6 (0.6, 0.6) 0.61 (0.61, 0.61) 0.6 (0.6, 0.6) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52) 0.53 (0.53, 0.53) 0.64 (0.64, 0.64)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.078 (0.078, 0.078) 0 (0, 0) 0.085 (0.085, 0.085) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Taxel_therapies count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
time 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5)
n 9 (7, 11) 2 (0, 2) 2 (1, 4) 3 (3, 4) 2 (2, 3) 0 (0, 2) 0 (0, 0) 1 (0, 1) 2 (0, 3) 1 (0, 2) 2 (1, 3) 1 (0, 3) 0 (0, 1) 0 (0, 3) 0 (0, 1) 0 (0, 1)
post_p 0.65 (0.62, 0.71) 0.56 (0.56, 0.56) 0.63 (0.6, 0.65) 0.68 (0.68, 0.7) 0.56 (0.54, 0.59) 0.6 (0.6, 0.6) NA (NA, NA) 0.53 (0.53, 0.53) 0.8 (0.76, 0.84) 0.61 (0.61, 0.61) 0.67 (0.63, 0.73) 0.55 (0.55, 0.55) 0.55 (0.55, 0.55) 0.69 (0.69, 0.69) 0.51 (0.51, 0.51) 0.57 (0.57, 0.57)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.075 (0.049, 0.099) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
DRD+ Carboplatin count 166 166 166 166 166 166 166 166
time 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32)
n 6 (3, 14) 5 (3, 15) 4 (2, 8) 4 (1, 9) 4 (1, 9) 4 (1, 8) 4 (2, 8) 4 (2, 8)
post_p 0.76 (0.58, 0.93) 0.71 (0.53, 0.83) 0.78 (0.57, 0.96) 0.71 (0.53, 0.88) 0.79 (0.58, 0.96) 0.7 (0.56, 0.88) 0.78 (0.59, 0.96) 0.72 (0.53, 0.87)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.028 (0, 0.061) 0.021 (0, 0.044) 0.025 (0, 0.066) 0.023 (0, 0.058) 0.025 (0, 0.068) 0.019 (0, 0.056) 0.034 (0, 0.076) 0.024 (0, 0.066)
Niraparib count 159 159 159 159 159 159 159 159
time 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32)
n 7 (3, 14) 7 (3, 16) 4 (1, 8) 4 (1, 9) 4 (2, 8) 4 (1, 8) 5 (1, 8) 4 (2, 8)
post_p 0.76 (0.57, 0.93) 0.73 (0.53, 0.87) 0.78 (0.55, 0.96) 0.72 (0.53, 0.89) 0.77 (0.57, 0.94) 0.71 (0.54, 0.9) 0.8 (0.58, 0.96) 0.72 (0.53, 0.92)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.029 (0, 0.057) 0.022 (0, 0.041) 0.03 (0, 0.068) 0.022 (0, 0.069) 0.031 (0, 0.076) 0.024 (0, 0.058) 0.029 (0, 0.064) 0.024 (0, 0.055)
Taxel_therapies count 3 3 3 3 3 3 3 3
time 13 (11, 14) 13 (11, 14) 13 (11, 14) 13 (11, 14) 13 (11, 14) 13 (11, 14) 13 (11, 14) 13 (11, 14)
n 4 (4, 5) 5 (4, 5) 4 (2, 5) 4 (3, 6) 1 (0, 3) 3 (2, 4) 1 (0, 1) 3 (2, 5)
post_p 0.54 (0.52, 0.55) 0.59 (0.55, 0.68) 0.61 (0.58, 0.67) 0.73 (0.65, 0.79) 0.64 (0.63, 0.64) 0.63 (0.57, 0.65) 0.56 (0.53, 0.58) 0.71 (0.67, 0.71)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.075 (0.058, 0.077) 0 (0, 0.024) 0.044 (0.009, 0.106) 0.043 (0.009, 0.054) 0.029 (0.006, 0.053) 0 (0, 0.081) 0 (0, 0) 0 (0, 0.044)
TEfus+ Carboplatin count 1 1 1 1 1 1 1 1
time 14 (14, 14) 14 (14, 14) 14 (14, 14) 14 (14, 14) 14 (14, 14) 14 (14, 14) 14 (14, 14) 14 (14, 14)
n 3 (3, 3) 5 (5, 5) 5 (5, 5) 3 (3, 3) 5 (5, 5) 1 (1, 1) 3 (3, 3) 4 (4, 4)
post_p 0.73 (0.73, 0.73) 0.65 (0.65, 0.65) 0.78 (0.78, 0.78) 0.66 (0.66, 0.66) 0.51 (0.51, 0.51) 0.69 (0.69, 0.69) 0.89 (0.89, 0.89) 0.75 (0.75, 0.75)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0.053 (0.053, 0.053) 0 (0, 0) 0 (0, 0) 0.158 (0.158, 0.158) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Hormone_therapies count 1 1 1 1 1 1 1 1
time 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10)
n 3 (3, 3) 5 (5, 5) 8 (8, 8) 1 (1, 1) 4 (4, 4) 4 (4, 4) 0 (0, 0) 0 (0, 0)
post_p 0.69 (0.69, 0.69) 0.77 (0.77, 0.77) 0.74 (0.74, 0.74) 0.54 (0.54, 0.54) 0.89 (0.89, 0.89) 0.66 (0.66, 0.66) NA (NA, NA) NA (NA, NA)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0 (0, 0) 0.043 (0.043, 0.043) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.078 (0.078, 0.078) NA (NA, NA) NA (NA, NA)
Niraparib count 3 3 3 3 3 3 3 3
time 9 (7, 12) 9 (7, 12) 9 (7, 12) 9 (7, 12) 9 (7, 12) 9 (7, 12) 9 (7, 12) 9 (7, 12)
n 2 (1, 4) 11 (9, 13) 4 (3, 5) 2 (1, 3) 2 (1, 3) 3 (1, 4) 2 (2, 3) 2 (2, 3)
post_p 0.52 (0.51, 0.56) 0.75 (0.72, 0.78) 0.7 (0.61, 0.75) 0.57 (0.56, 0.63) 0.6 (0.57, 0.68) 0.62 (0.53, 0.7) 0.54 (0.52, 0.83) 0.54 (0.53, 0.62)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0.093) 0.082 (0.041, 0.107) 0 (0, 0) 0 (0, 0) 0.093 (0.019, 0.122) 0.031 (0.006, 0.055) 0 (0, 0.03) 0 (0, 0.069)
Taxel_therapies count 167 167 167 167 167 167 167 167
time 15 (10, 31) 15 (10, 31) 15 (10, 31) 15 (10, 31) 15 (10, 31) 15 (10, 31) 15 (10, 31) 15 (10, 31)
n 5 (2, 13) 10 (5, 22) 5 (2, 12) 3 (1, 9) 4 (1, 9) 4 (2, 10) 3 (1, 7) 3 (1, 8)
post_p 0.75 (0.57, 0.9) 0.9 (0.73, 0.99) 0.69 (0.53, 0.83) 0.67 (0.52, 0.86) 0.78 (0.6, 0.97) 0.77 (0.57, 0.97) 0.66 (0.53, 0.83) 0.68 (0.52, 0.88)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.026 (0, 0.061) 0.037 (0, 0.069) 0.013 (0, 0.042) 0.008 (0, 0.064) 0.025 (0, 0.08) 0.028 (0, 0.076) 0.017 (0, 0.061) 0.019 (0, 0.063)
TP53- & AR- Carboplatin count 2 2 2 2
time 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10)
n 16 (15, 18) 2 (1, 4) 3 (3, 3) 4 (3, 6)
post_p 0.81 (0.76, 0.86) 0.63 (0.57, 0.69) 0.61 (0.55, 0.67) 0.78 (0.78, 0.79)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.065 (0.04, 0.09) 0.024 (0.005, 0.043) 0.062 (0.012, 0.112) 0 (0, 0)
Hormone_therapies count 272 272 272 272
time 12 (9, 28) 12 (9, 28) 12 (9, 28) 12 (9, 28)
n 21 (15, 51) 4 (2, 10) 4 (2, 11) 4 (1, 11)
post_p 0.96 (0.82, 1) 0.71 (0.54, 0.87) 0.71 (0.54, 0.86) 0.63 (0.52, 0.78)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.039 (0.017, 0.062) 0.027 (0, 0.076) 0.017 (0, 0.064) 0 (0, 0.053)
Niraparib count 2 2 2 2
time 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13)
n 26 (21, 30) 2 (1, 4) 5 (5, 5) 5 (4, 6)
post_p 0.78 (0.77, 0.79) 0.54 (0.53, 0.55) 0.87 (0.82, 0.91) 0.72 (0.57, 0.87)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.092 (0.076, 0.108) 0.045 (0.009, 0.081) 0 (0, 0) 0 (0, 0)
Taxel_therapies count 5 5 5 5
time 11 (8, 12) 11 (8, 12) 11 (8, 12) 11 (8, 12)
n 22 (17, 25) 4 (3, 6) 2 (0, 3) 1 (0, 4)
post_p 0.76 (0.72, 0.8) 0.75 (0.68, 0.87) 0.57 (0.54, 0.66) 0.67 (0.57, 0.75)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.072 (0.059, 0.102) 0 (0, 0.072) 0 (0, 0.027) 0 (0, 0)
TP53+ Carboplatin count 3 3 3 3 3 3 3 3
time 11 (9, 18) 11 (9, 18) 11 (9, 18) 11 (9, 18) 11 (9, 18) 11 (9, 18) 11 (9, 18) 11 (9, 18)
n 14 (7, 16) 4 (3, 5) 3 (2, 3) 1 (0, 6) 3 (2, 5) 1 (0, 3) 3 (1, 5) 5 (3, 5)
post_p 0.85 (0.57, 0.88) 0.69 (0.62, 0.74) 0.7 (0.56, 0.72) 0.69 (0.6, 0.78) 0.61 (0.58, 0.64) 0.56 (0.55, 0.57) 0.68 (0.55, 0.86) 0.72 (0.68, 0.8)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.136 (0.123, 0.142) 0 (0, 0.066) 0 (0, 0.047) 0 (0, 0) 0.067 (0.013, 0.145) 0.035 (0.007, 0.063) 0 (0, 0.03) 0 (0, 0.016)
Hormone_therapies count 1 1 1 1 1 1 1 1
time 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7)
n 6 (6, 6) 6 (6, 6) 1 (1, 1) 1 (1, 1) 1 (1, 1) 1 (1, 1) 2 (2, 2) 7 (7, 7)
post_p 0.87 (0.87, 0.87) 0.76 (0.76, 0.76) 0.53 (0.53, 0.53) NA (NA, NA) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.08 (0.08, 0.08) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1.02 (1.02, 1.02) 0.167 (0.167, 0.167) 0.055 (0.055, 0.055)
Niraparib count 4 4 4 4 4 4 4 4
time 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14)
n 12 (11, 14) 8 (5, 10) 2 (1, 4) 2 (1, 4) 2 (0, 4) 2 (2, 4) 2 (1, 3) 2 (1, 4)
post_p 0.76 (0.74, 0.85) 0.72 (0.66, 0.73) 0.7 (0.56, 0.79) 0.57 (0.5, 0.68) 0.6 (0.52, 0.67) 0.68 (0.57, 0.77) 0.74 (0.58, 0.86) 0.56 (0.53, 0.68)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.105 (0.078, 0.131) 0.08 (0.057, 0.126) 0.029 (0, 0.06) 0 (0, 0.025) 0.122 (0.076, 0.168) 0.056 (0.016, 0.065) 0 (0, 0) 0.027 (0.005, 0.033)
Taxel_therapies count 12 12 12 12 12 12 12 12
time 11 (8, 16) 11 (8, 16) 11 (8, 16) 11 (8, 16) 11 (8, 16) 11 (8, 16) 11 (8, 16) 11 (8, 16)
n 10 (6, 18) 8 (5, 12) 2 (1, 3) 3 (1, 5) 3 (1, 4) 3 (1, 7) 2 (0, 3) 2 (0, 5)
post_p 0.78 (0.71, 0.9) 0.83 (0.73, 0.93) 0.58 (0.51, 0.7) 0.68 (0.52, 0.76) 0.64 (0.55, 0.83) 0.72 (0.57, 0.85) 0.53 (0.5, 0.7) 0.54 (0.52, 0.59)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.101 (0.08, 0.149) 0.034 (0, 0.057) 0.025 (0, 0.166) 0 (0, 0.073) 0.091 (0.046, 0.125) 0.01 (0, 0.068) 0 (0, 0.101) 0 (0, 0.068)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4)
n 6 (6, 6) 1 (1, 1) 2 (2, 2) 4 (4, 4) 0 (0, 0) 2 (2, 2) 1 (1, 1) 2 (2, 2) 3 (3, 3) 4 (4, 4) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (2, 2) 2 (2, 2)
post_p 0.44 (0.44, 0.44) 0.46 (0.46, 0.46) 0.35 (0.35, 0.35) NA (NA, NA) NA (NA, NA) 0.25 (0.25, 0.25) NA (NA, NA) 0.37 (0.37, 0.37) NA (NA, NA) NA (NA, NA) 0.28 (0.28, 0.28) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.36 (0.36, 0.36) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.182 (0.182, 0.182) 0 (0, 0) 0.327 (0.327, 0.327) 0 (0, 0) NA (NA, NA) 0.194 (0.194, 0.194) 0 (0, 0) 0.246 (0.246, 0.246) 0.348 (0.348, 0.348) 0 (0, 0) 3.745 (3.745, 3.745) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.274 (0.274, 0.274) 0.489 (0.489, 0.489)
DRD+ count 75 75 75 75 75 75 75 75
time 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32)
n 5 (2, 10) 5 (2, 12) 4 (2, 7) 4 (1, 7) 4 (1, 8) 4 (1, 9) 4 (1, 7) 3 (1, 8)
post_p 0.4 (0.21, 0.49) 0.37 (0.18, 0.48) 0.3 (0.15, 0.47) 0.21 (0.07, 0.36) 0.29 (0.13, 0.48) 0.27 (0.08, 0.45) 0.3 (0.09, 0.44) 0.25 (0.07, 0.45)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.086 (0.056, 0.146) 0.057 (0.036, 0.117) 0.2 (0.114, 0.413) 0.173 (0.093, 0.72) 0.183 (0.113, 0.393) 0.147 (0.081, 0.38) 0.199 (0.087, 0.406) 0.182 (0.078, 0.45)
Taxel_therapies count 7 7 7 7 7 7 7 7
time 18 (16, 33) 18 (16, 33) 18 (16, 33) 18 (16, 33) 18 (16, 33) 18 (16, 33) 18 (16, 33) 18 (16, 33)
n 6 (5, 17) 8 (7, 17) 2 (1, 9) 5 (2, 10) 5 (4, 10) 3 (0, 6) 6 (4, 8) 4 (1, 8)
post_p 0.17 (0.05, 0.38) 0.38 (0.28, 0.42) 0.29 (0.18, 0.4) 0.39 (0.22, 0.47) 0.15 (0.09, 0.27) 0.34 (0.25, 0.36) 0.39 (0.26, 0.47) 0.36 (0.2, 0.44)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.118 (0.069, 0.204) 0.049 (0.045, 0.083) 0.191 (0.161, 1.214) 0.078 (0.058, 0.323) 0.194 (0.153, 0.424) 0.125 (0.062, 1.455) 0.131 (0.116, 0.18) 0.105 (0.04, 0.159)
TEfus+ Carboplatin count 6 6 6 6 6 6 6 6
time 12 (12, 28) 12 (12, 28) 12 (12, 28) 12 (12, 28) 12 (12, 28) 12 (12, 28) 12 (12, 28) 12 (12, 28)
n 5 (4, 11) 7 (5, 21) 5 (4, 12) 4 (2, 5) 6 (2, 10) 6 (2, 10) 2 (0, 8) 2 (1, 4)
post_p 0.22 (0.1, 0.36) 0.26 (0.06, 0.39) 0.36 (0.21, 0.46) 0.38 (0.3, 0.42) 0.27 (0.1, 0.43) 0.25 (0.12, 0.31) 0.36 (0.18, 0.41) 0.45 (0.24, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.19 (0.119, 0.566) 0.167 (0.147, 0.291) 0.056 (0.039, 0.078) 0.071 (0.038, 0.087) 0.21 (0.17, 0.334) 0.182 (0.153, 0.517) 0.143 (0.076, 0.537) 0.067 (0.025, 0.332)
Hormone_therapies count 93 93 93 93 93 93 93 93
time 22 (11, 35) 22 (11, 35) 22 (11, 35) 22 (11, 35) 22 (11, 35) 22 (11, 35) 22 (11, 35) 22 (11, 35)
n 5 (2, 12) 12 (6, 24) 5 (2, 12) 4 (1, 9) 6 (3, 10) 5 (2, 10) 4 (2, 9) 4 (2, 9)
post_p 0.42 (0.29, 0.49) 0.21 (0.04, 0.39) 0.39 (0.18, 0.49) 0.24 (0.07, 0.4) 0.29 (0.08, 0.47) 0.3 (0.09, 0.44) 0.24 (0.07, 0.45) 0.23 (0.06, 0.43)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.086 (0.055, 0.154) 0.163 (0.117, 0.238) 0.06 (0.032, 0.129) 0.168 (0.08, 0.43) 0.181 (0.104, 0.445) 0.185 (0.1, 0.398) 0.167 (0.073, 0.412) 0.146 (0.079, 0.489)
Niraparib count 11 11 11 11 11 11 11 11
time 19 (10, 25) 19 (10, 25) 19 (10, 25) 19 (10, 25) 19 (10, 25) 19 (10, 25) 19 (10, 25) 19 (10, 25)
n 5 (2, 7) 12 (7, 21) 5 (0, 9) 2 (0, 4) 6 (4, 10) 4 (3, 5) 2 (0, 7) 2 (1, 8)
post_p 0.25 (0.05, 0.4) 0.21 (0.11, 0.43) 0.39 (0.24, 0.48) 0.41 (0.28, 0.5) 0.32 (0.24, 0.42) 0.34 (0.24, 0.45) 0.46 (0.44, 0.49) 0.35 (0.27, 0.45)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.189 (0.127, 0.526) 0.171 (0.113, 0.262) 0.067 (0.027, 0.084) 0.103 (0.042, 0.24) 0.18 (0.134, 0.397) 0.179 (0.115, 0.328) 0.071 (0.029, 0.918) 0.111 (0.077, 0.239)
TP53- & AR- Carboplatin count 122 122 122 122
time 13 (9, 23) 13 (9, 23) 13 (9, 23) 13 (9, 23)
n 22 (15, 43) 4 (2, 10) 4 (2, 9) 5 (2, 9)
post_p 0.13 (0.01, 0.36) 0.28 (0.06, 0.46) 0.45 (0.34, 0.49) 0.4 (0.23, 0.49)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.161 (0.121, 0.212) 0.164 (0.071, 0.384) 0.083 (0.042, 0.195) 0.06 (0.026, 0.147)
Niraparib count 110 110 110 110
time 13 (9, 21) 13 (9, 21) 13 (9, 21) 13 (9, 21)
n 21 (15, 38) 5 (2, 9) 4 (1, 9) 4 (2, 9)
post_p 0.16 (0.02, 0.43) 0.26 (0.05, 0.45) 0.42 (0.26, 0.49) 0.4 (0.25, 0.49)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.152 (0.116, 0.208) 0.167 (0.087, 0.396) 0.082 (0.047, 0.182) 0.063 (0.022, 0.207)
Taxel_therapies count 105 105 105 105
time 14 (9, 24) 14 (9, 24) 14 (9, 24) 14 (9, 24)
n 24 (15, 42) 4 (1, 8) 5 (2, 10) 5 (2, 10)
post_p 0.09 (0, 0.33) 0.45 (0.34, 0.49) 0.25 (0.05, 0.44) 0.4 (0.24, 0.48)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.156 (0.123, 0.224) 0.095 (0.045, 0.213) 0.155 (0.085, 0.315) 0.058 (0.03, 0.146)
TP53+ Carboplatin count 3 3 3 3 3 3 3 3
time 13 (12, 15) 13 (12, 15) 13 (12, 15) 13 (12, 15) 13 (12, 15) 13 (12, 15) 13 (12, 15) 13 (12, 15)
n 13 (12, 22) 5 (4, 11) 0 (0, 2) 2 (2, 4) 4 (2, 6) 4 (4, 6) 1 (0, 1) 3 (1, 5)
post_p 0.28 (0.1, 0.28) 0.2 (0.11, 0.23) 0.46 (0.46, 0.46) 0.48 (0.35, 0.49) 0.39 (0.16, 0.39) 0.25 (0.19, 0.31) 0.44 (0.39, 0.49) 0.47 (0.46, 0.47)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.168 (0.155, 0.328) 0.192 (0.158, 0.232) 0.13 (0.13, 0.13) 0.027 (0.005, 0.072) 0.374 (0.246, 0.516) 0.221 (0.183, 0.316) 0.082 (0.016, 0.147) 0.049 (0.01, 0.058)
Hormone_therapies count 254 254 254 254 254 254 254 254
time 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32)
n 18 (8, 35) 11 (6, 23) 4 (1, 8) 4 (1, 8) 5 (1, 10) 5 (2, 10) 4 (1, 8) 4 (1, 8)
post_p 0.34 (0.1, 0.48) 0.19 (0.03, 0.42) 0.33 (0.12, 0.48) 0.24 (0.08, 0.45) 0.37 (0.19, 0.48) 0.33 (0.12, 0.47) 0.27 (0.09, 0.46) 0.25 (0.07, 0.43)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.178 (0.14, 0.263) 0.163 (0.113, 0.266) 0.174 (0.101, 0.434) 0.165 (0.076, 0.466) 0.201 (0.138, 0.443) 0.175 (0.098, 0.376) 0.19 (0.097, 0.467) 0.178 (0.086, 0.435)
Niraparib count 3 3 3 3 3 3 3 3
time 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13)
n 10 (9, 15) 10 (8, 12) 2 (0, 3) 3 (2, 4) 2 (2, 3) 3 (1, 5) 1 (0, 1) 3 (1, 4)
post_p 0.4 (0.19, 0.45) 0.21 (0.11, 0.32) 0.44 (0.4, 0.48) 0.28 (0.25, 0.4) 0.37 (0.36, 0.39) 0.41 (0.34, 0.44) 0.48 (0.46, 0.49) 0.42 (0.42, 0.43)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.199 (0.159, 0.262) 0.188 (0.18, 0.214) 0.077 (0.049, 0.104) 0.178 (0.134, 0.245) 0.164 (0.144, 0.268) 0.125 (0.124, 0.336) 0.11 (0.022, 0.198) 0.085 (0.078, 0.093)