Simulation scenario 10

Setting description

Equal randomization: several treatments more effective in distinctive signatures (cfr scen 7)

Simulations setting

PFS distributions

Treatment effects

By subgroup:

subtype	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	param	scale = 0.112, shape = 1.05	scale = 0.043, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 22.6, median = 16.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 2.58, hr = 0.37	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
—+	param	scale = 0.112, shape = 1.05	scale = 0.043, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 22.6, median = 16.3	mean = 25, median = 18	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 2.58, hr = 0.37	af = 2.85, hr = 0.33	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
–+-	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
–++	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 25, median = 18	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 2.85, hr = 0.33	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
-+–	param	scale = 0.112, shape = 1.05	scale = 0.043, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 22.6, median = 16.3	mean = 6.3, median = 4.5	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 2.58, hr = 0.37	af = 0.71, hr = 1.43	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.043, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 22.6, median = 16.3	mean = 25, median = 18	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 2.58, hr = 0.37	af = 2.85, hr = 0.33	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-++-	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-+++	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 25, median = 18	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 2.85, hr = 0.33	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
+—	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
+–+	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 25, median = 18	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 2.85, hr = 0.33	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
+-++	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 25, median = 18	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 2.85, hr = 0.33	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
++–	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
++-+	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 25, median = 18	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 2.85, hr = 0.33	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
+++-	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
++++	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 25, median = 18	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 2.85, hr = 0.33	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31

By signature:

signature	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	param	scale = 0.112, shape = 1.05	scale = 0.129, shape = 1.05	scale = 0.099, shape = 1.05	scale = 0.098, shape = 1.05	scale = 0.098, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 7.6, median = 5.5	mean = 9.9, median = 7.1	mean = 10, median = 7.2	mean = 10, median = 7.2
	effect	af = 1, hr = 1	af = 0.87, hr = 1.16	af = 1.13, hr = 0.88	af = 1.14, hr = 0.87	af = 1.14, hr = 0.87
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.043, shape = 1.05	scale = 0.099, shape = 1.05	scale = 0.098, shape = 1.05	scale = 0.098, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 22.6, median = 16.3	mean = 9.9, median = 7.1	mean = 10, median = 7.2	mean = 10, median = 7.2
	effect	af = 1, hr = 1	af = 2.58, hr = 0.37	af = 1.13, hr = 0.88	af = 1.14, hr = 0.87	af = 1.14, hr = 0.87
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.099, shape = 1.05	scale = 0.098, shape = 1.05	scale = 0.098, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 9.9, median = 7.1	mean = 10, median = 7.2	mean = 10, median = 7.2
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 1.13, hr = 0.88	af = 1.14, hr = 0.87	af = 1.14, hr = 0.87
DRD+	param	scale = 0.112, shape = 1.05	scale = 0.129, shape = 1.05	scale = 0.099, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 7.6, median = 5.5	mean = 9.9, median = 7.1	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.87, hr = 1.16	af = 1.13, hr = 0.88	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.129, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.098, shape = 1.05	scale = 0.098, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 7.6, median = 5.5	mean = 25, median = 18	mean = 10, median = 7.2	mean = 10, median = 7.2
	effect	af = 1, hr = 1	af = 0.87, hr = 1.16	af = 2.85, hr = 0.33	af = 1.14, hr = 0.87	af = 1.14, hr = 0.87

Errors and power

graduation (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 3 3 0 1 TP53- & AR- 272 5 2 2 TP53+ 1 12 3 4 DRD+ 0 3 166 159 TEfus+ 1 167 1 3

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.006 0.006 0.000 0.002 TP53- & AR- 0.544 0.010 0.004 0.004 TP53+ 0.002 0.024 0.006 0.008 DRD+ 0.000 0.006 0.332 0.318 TEfus+ 0.002 0.334 0.002 0.006

futility (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 1 0 0 0 TP53- & AR- 0 105 122 110 TP53+ 254 0 3 3 DRD+ 75 7 0 0 TEfus+ 93 0 6 11

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.002 0.000 0.000 0.000 TP53- & AR- 0.000 0.210 0.244 0.220 TP53+ 0.508 0.000 0.006 0.006 DRD+ 0.150 0.014 0.000 0.000 TEfus+ 0.186 0.000 0.012 0.022

max sample size (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 0 0 TP53- & AR- 8 11 14 17 TP53+ 1 9 14 13 DRD+ 0 0 0 0 TEfus+ 0 1 0 2

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.000 0.000 TP53- & AR- 0.016 0.022 0.028 0.034 TP53+ 0.002 0.018 0.028 0.026 DRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.000 0.002 0.000 0.004

Errors & power

The overall error was 0.048.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.008             0.026             0.006             0.008 

The overall power was 0.858.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.544             0.334             0.332             0.318 

Median results at the end of the trial

By signature:

signature	var	Carboplatin	Control	Hormone_therapies	Niraparib	Taxel_therapies
all	graduation	0	0	3	1	3
	futility	0	0	1	0	0
	max_n	0	0	0	0	0
	n	248 (180, 292)	276 (244, 311)	186 (121, 253)	244 (182, 292)	236 (177, 287)
	n_unique	225 (164, 266)	252 (226, 284)	167 (106, 230)	221 (165, 268)	216 (160, 262)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	NA (NA, NA)	4 (4, 4)	5 (5, 5)	4 (4, 5)
	post_p	0.24 (0.01, 0.71)	NA (NA, NA)	0.47 (0.02, 0.98)	0.23 (0.01, 0.71)	0.53 (0.06, 0.94)
	rate	0.1 (0.09, 0.115)	0.093 (0.084, 0.102)	0.092 (0.075, 0.115)	0.101 (0.09, 0.114)	0.092 (0.079, 0.109)
DRD+	graduation	166	0	0	159	3
	futility	0	0	75	0	7
	max_n	0	0	0	0	0
	n	67 (28, 90)	82 (67, 99)	52 (31, 77)	67 (30, 89)	68 (45, 93)
	n_unique	60 (25, 81)	76 (61, 92)	46 (27, 71)	61 (27, 80)	60 (40, 83)
	time_trial	36 (16, 36)	36 (36, 36)	36 (22, 36)	36 (16, 36)	36 (36, 36)
	time_stop	20 (12, 32)	NA (NA, NA)	20 (14, 32)	20 (13, 32)	17 (13, 33)
	post_p	1 (0.99, 1)	NA (NA, NA)	0.15 (0.01, 0.64)	1 (0.99, 1)	0.52 (0.12, 0.92)
	rate	0.036 (0.027, 0.044)	0.089 (0.074, 0.107)	0.099 (0.076, 0.135)	0.035 (0.027, 0.044)	0.079 (0.061, 0.1)
TEfus+	graduation	1	0	1	3	167
	futility	6	0	93	11	0
	max_n	0	0	0	2	1
	n	94 (69, 119)	105 (87, 124)	70 (36, 101)	91 (69, 118)	86 (28, 114)
	n_unique	85 (63, 107)	96 (80, 114)	63 (32, 89)	83 (62, 107)	77 (25, 101)
	time_trial	36 (36, 36)	36 (36, 36)	36 (22, 36)	36 (36, 36)	36 (12, 36)
	time_stop	13 (12, 26)	NA (NA, NA)	22 (11, 35)	16 (9, 24)	15 (10, 31)
	post_p	0.16 (0.01, 0.55)	NA (NA, NA)	0.02 (0, 0.23)	0.17 (0.02, 0.55)	1 (0.98, 1)
	rate	0.09 (0.073, 0.109)	0.074 (0.063, 0.086)	0.11 (0.086, 0.139)	0.088 (0.073, 0.107)	0.038 (0.03, 0.046)
TP53- & AR-	graduation	2	0	272	2	5
	futility	122	0	0	110	105
	max_n	14	0	8	17	11
	n	100 (30, 130)	115 (96, 143)	73 (26, 116)	100 (31, 129)	100 (32, 131)
	n_unique	92 (28, 117)	106 (88, 133)	68 (24, 106)	91 (28, 118)	92 (29, 120)
	time_trial	36 (12, 36)	36 (36, 36)	29 (9, 36)	36 (12, 36)	36 (13, 36)
	time_stop	13 (9, 23)	NA (NA, NA)	12 (9, 28)	13 (9, 21)	13 (9, 23)
	post_p	0.02 (0, 0.24)	NA (NA, NA)	1 (0.93, 1)	0.02 (0, 0.2)	0.02 (0, 0.2)
	rate	0.106 (0.088, 0.128)	0.073 (0.062, 0.085)	0.042 (0.034, 0.051)	0.105 (0.09, 0.13)	0.109 (0.09, 0.134)
TP53+	graduation	3	0	1	4	12
	futility	3	0	254	3	0
	max_n	14	0	1	13	9
	n	114 (90, 137)	119 (103, 138)	89 (33, 119)	113 (91, 136)	108 (78, 133)
	n_unique	104 (82, 124)	108 (93, 127)	81 (30, 108)	102 (82, 124)	97 (72, 120)
	time_trial	36 (36, 36)	36 (36, 36)	35 (12, 36)	36 (36, 36)	36 (36, 36)
	time_stop	12 (10, 18)	NA (NA, NA)	18 (10, 32)	11 (9, 14)	11 (8, 16)
	post_p	0.7 (0.22, 0.97)	NA (NA, NA)	0.02 (0, 0.13)	0.69 (0.22, 0.97)	0.96 (0.63, 1)
	rate	0.103 (0.088, 0.12)	0.112 (0.098, 0.129)	0.162 (0.138, 0.194)	0.103 (0.088, 0.123)	0.084 (0.069, 0.105)

By subgroup combinations:

subtype	var	Carboplatin	Control	Hormone_therapies	Niraparib	Taxel_therapies
—-	graduation	124	0	276	113	113
	futility	0	0	0	0	0
	max_n	14	0	8	17	11
	n	62 (19, 81)	70 (55, 88)	47 (16, 72)	63 (20, 81)	62 (22, 83)
	n_unique	58 (18, 76)	64 (50, 84)	44 (15, 68)	59 (19, 75)	58 (21, 78)
	post_p	0 (0, 0.06)	NA (NA, NA)	1 (0.96, 1)	0 (0, 0.05)	0 (0, 0.06)
	rate	0.158 (0.132, 0.193)	0.083 (0.067, 0.101)	0.043 (0.032, 0.056)	0.161 (0.135, 0.191)	0.158 (0.132, 0.193)
—+	graduation	128	0	343	122	256
	futility	0	0	0	0	0
	max_n	14	0	8	17	12
	n	14 (4, 20)	15 (10, 22)	7 (2, 17)	13 (4, 21)	10 (2, 18)
	n_unique	12 (3, 18)	14 (9, 20)	6 (2, 15)	12 (4, 19)	9 (2, 17)
	post_p	0.04 (0, 0.23)	NA (NA, NA)	0.75 (0.41, 0.96)	0.05 (0, 0.25)	0.83 (0.43, 0.97)
	rate	0.161 (0.109, 0.266)	0.051 (0.03, 0.081)	0.044 (0.021, 0.08)	0.159 (0.105, 0.261)	0.038 (0.02, 0.075)
–+-	graduation	6	0	259	8	15
	futility	0	0	0	0	0
	max_n	14	0	1	13	9
	n	37 (28, 46)	38 (29, 46)	29 (10, 41)	38 (28, 47)	37 (28, 46)
	n_unique	34 (26, 43)	34 (26, 43)	27 (10, 37)	34 (26, 43)	34 (25, 42)
	post_p	0.4 (0.07, 0.82)	NA (NA, NA)	0.4 (0.09, 0.78)	0.37 (0.07, 0.8)	0.38 (0.07, 0.79)
	rate	0.159 (0.128, 0.206)	0.146 (0.115, 0.181)	0.163 (0.127, 0.224)	0.163 (0.128, 0.206)	0.161 (0.129, 0.202)
–++	graduation	12	0	305	22	177
	futility	0	0	0	0	0
	max_n	14	0	1	14	10
	n	27 (19, 35)	26 (19, 34)	18 (7, 30)	26 (18, 34)	22 (8, 31)
	n_unique	24 (17, 33)	24 (17, 32)	16 (6, 27)	24 (17, 31)	20 (7, 28)
	post_p	0.05 (0, 0.27)	NA (NA, NA)	0.08 (0.01, 0.32)	0.06 (0, 0.27)	0.99 (0.9, 1)
	rate	0.156 (0.121, 0.201)	0.085 (0.059, 0.122)	0.161 (0.12, 0.23)	0.158 (0.119, 0.206)	0.039 (0.022, 0.055)
-+–	graduation	252	0	328	249	122
	futility	0	0	0	0	0
	max_n	11	0	8	17	11
	n	10 (3, 18)	15 (9, 21)	7 (2, 17)	10 (3, 19)	13 (4, 20)
	n_unique	9 (3, 16)	14 (8, 20)	6 (2, 15)	10 (3, 17)	12 (4, 18)
	post_p	0.86 (0.51, 0.98)	NA (NA, NA)	0.77 (0.43, 0.93)	0.85 (0.53, 0.98)	0.05 (0, 0.26)
	rate	0.035 (0.018, 0.069)	0.08 (0.053, 0.125)	0.043 (0.021, 0.081)	0.037 (0.02, 0.067)	0.162 (0.104, 0.228)
-+-+	graduation	255	0	376	255	262
	futility	0	0	0	0	0
	max_n	11	0	8	17	12
	n	10 (3, 21)	16 (10, 23)	6 (2, 18)	11 (3, 20)	10 (3, 20)
	n_unique	9 (3, 18)	15 (9, 21)	5 (2, 15)	10 (3, 18)	9 (2, 18)
	post_p	0.63 (0.28, 0.88)	NA (NA, NA)	0.55 (0.25, 0.81)	0.63 (0.3, 0.88)	0.58 (0.26, 0.88)
	rate	0.037 (0.018, 0.066)	0.053 (0.032, 0.079)	0.042 (0.018, 0.079)	0.036 (0.018, 0.064)	0.039 (0.018, 0.069)
-++-	graduation	170	0	294	164	25
	futility	0	0	0	0	0
	max_n	14	0	1	11	9
	n	7 (3, 11)	8 (4, 12)	5 (2, 11)	7 (3, 12)	8 (4, 13)
	n_unique	6 (2, 11)	7 (4, 11)	5 (1, 10)	6 (2, 11)	7 (3, 11)
	post_p	0.93 (0.69, 0.99)	NA (NA, NA)	0.28 (0.09, 0.55)	0.92 (0.69, 0.99)	0.25 (0.04, 0.53)
	rate	0.034 (0.013, 0.07)	0.151 (0.087, 0.267)	0.168 (0.101, 0.36)	0.035 (0.015, 0.071)	0.167 (0.094, 0.283)
-+++	graduation	175	0	329	175	184
	futility	0	0	0	0	0
	max_n	14	0	1	12	10
	n	7 (3, 12)	9 (5, 13)	5 (1, 10)	7 (2, 12)	7 (2, 12)
	n_unique	6 (2, 11)	8 (5, 13)	4 (1, 9)	6 (2, 11)	6 (2, 11)
	post_p	0.76 (0.46, 0.93)	NA (NA, NA)	0.16 (0.03, 0.38)	0.76 (0.45, 0.94)	0.73 (0.46, 0.93)
	rate	0.034 (0.013, 0.072)	0.087 (0.044, 0.158)	0.164 (0.097, 0.378)	0.035 (0.013, 0.078)	0.038 (0.015, 0.077)
+—	graduation	0	0	4	1	3
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	12 (8, 17)	12 (7, 17)	12 (7, 16)	12 (8, 17)	12 (8, 17)
	n_unique	11 (7, 15)	11 (6, 15)	10 (6, 15)	11 (7, 16)	11 (7, 16)
	post_p	0.47 (0.14, 0.82)	NA (NA, NA)	0.42 (0.12, 0.81)	0.46 (0.12, 0.8)	0.47 (0.12, 0.84)
	rate	0.155 (0.104, 0.24)	0.145 (0.093, 0.222)	0.166 (0.112, 0.257)	0.161 (0.11, 0.252)	0.16 (0.106, 0.254)
+–+	graduation	7	0	98	15	170
	futility	0	0	0	0	0
	max_n	0	0	0	2	1
	n	10 (6, 15)	10 (6, 15)	9 (4, 15)	10 (6, 14)	8 (3, 14)
	n_unique	9 (5, 14)	9 (6, 14)	8 (4, 13)	9 (5, 13)	7 (2, 12)
	post_p	0.2 (0.03, 0.51)	NA (NA, NA)	0.21 (0.04, 0.53)	0.2 (0.04, 0.52)	0.94 (0.67, 1)
	rate	0.163 (0.106, 0.255)	0.087 (0.048, 0.153)	0.166 (0.102, 0.278)	0.168 (0.107, 0.267)	0.038 (0.017, 0.076)
+-+-	graduation	6	0	259	8	15
	futility	0	0	0	0	0
	max_n	14	0	1	13	9
	n	10 (6, 15)	10 (6, 15)	8 (2, 13)	10 (5, 14)	10 (6, 14)
	n_unique	9 (5, 13)	9 (5, 13)	6 (2, 11)	9 (5, 13)	9 (5, 13)
	post_p	0.46 (0.15, 0.8)	NA (NA, NA)	0.42 (0.17, 0.76)	0.47 (0.16, 0.81)	0.48 (0.16, 0.81)
	rate	0.16 (0.105, 0.268)	0.151 (0.095, 0.236)	0.175 (0.115, 0.34)	0.16 (0.107, 0.261)	0.157 (0.104, 0.249)
+-++	graduation	12	0	305	22	177
	futility	0	0	0	0	0
	max_n	14	0	1	14	10
	n	11 (7, 16)	11 (7, 16)	7 (2, 12)	10 (6, 16)	8 (3, 14)
	n_unique	10 (6, 14)	10 (6, 14)	6 (2, 12)	9 (5, 14)	7 (2, 13)
	post_p	0.19 (0.04, 0.49)	NA (NA, NA)	0.24 (0.06, 0.5)	0.19 (0.04, 0.49)	0.94 (0.66, 0.99)
	rate	0.16 (0.109, 0.253)	0.087 (0.05, 0.152)	0.173 (0.107, 0.336)	0.164 (0.107, 0.262)	0.039 (0.018, 0.078)
++–	graduation	166	0	79	160	13
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	6 (3, 11)	8 (5, 12)	7 (4, 12)	6 (3, 11)	8 (4, 12)
	n_unique	6 (2, 10)	7 (4, 11)	7 (3, 11)	6 (2, 10)	7 (4, 11)
	post_p	0.92 (0.67, 0.99)	NA (NA, NA)	0.24 (0.07, 0.5)	0.91 (0.69, 0.99)	0.24 (0.07, 0.57)
	rate	0.035 (0.013, 0.077)	0.152 (0.09, 0.261)	0.167 (0.1, 0.311)	0.036 (0.015, 0.073)	0.158 (0.095, 0.293)
++-+	graduation	172	0	147	171	177
	futility	0	0	0	0	0
	max_n	0	0	0	2	1
	n	7 (2, 11)	8 (5, 13)	7 (3, 11)	7 (2, 12)	7 (2, 12)
	n_unique	6 (2, 10)	8 (4, 12)	6 (2, 10)	6 (2, 11)	6 (2, 11)
	post_p	0.76 (0.48, 0.94)	NA (NA, NA)	0.13 (0.02, 0.34)	0.78 (0.45, 0.94)	0.76 (0.44, 0.93)
	rate	0.035 (0.014, 0.069)	0.089 (0.044, 0.169)	0.166 (0.099, 0.304)	0.036 (0.014, 0.073)	0.037 (0.017, 0.08)
+++-	graduation	170	0	294	164	25
	futility	0	0	0	0	0
	max_n	14	0	1	11	9
	n	7 (3, 11)	8 (5, 13)	5 (2, 10)	7 (3, 12)	8 (4, 13)
	n_unique	6 (2, 10)	8 (4, 12)	5 (1, 9)	6 (2, 11)	7 (3, 11)
	post_p	0.92 (0.69, 0.99)	NA (NA, NA)	0.27 (0.09, 0.53)	0.93 (0.72, 0.99)	0.24 (0.06, 0.58)
	rate	0.035 (0.015, 0.069)	0.153 (0.088, 0.265)	0.173 (0.101, 0.343)	0.034 (0.012, 0.069)	0.159 (0.096, 0.268)
++++	graduation	175	0	329	175	184
	futility	0	0	0	0	0
	max_n	14	0	1	12	10
	n	7 (3, 13)	9 (5, 13)	5 (2, 10)	7 (3, 12)	7 (2, 12)
	n_unique	6 (2, 11)	8 (4, 12)	5 (1, 9)	6 (2, 11)	6 (2, 11)
	post_p	0.78 (0.46, 0.95)	NA (NA, NA)	0.17 (0.03, 0.36)	0.78 (0.46, 0.95)	0.75 (0.44, 0.93)
	rate	0.034 (0.013, 0.074)	0.094 (0.047, 0.181)	0.173 (0.093, 0.373)	0.034 (0.013, 0.069)	0.04 (0.015, 0.078)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	Hormone_therapies	Taxel_therapies	Niraparib	Carboplatin
all	count	3	3	1
	time_stop	4 (4, 4)	4 (4, 5)	5 (5, 5)
	n_trt	28 (26, 29)	27 (25, 32)	33 (33, 33)
	n_control	24 (22, 30)	24 (17, 35)	23 (23, 23)
	post_p	0.9 (0.86, 0.91)	0.97 (0.92, 0.97)	0.9 (0.9, 0.9)
	order	1 (1, 1)	1 (1, 1)	1 (1, 1)
TP53- & AR-	count	272	5	2	2
	time_stop	12 (9, 28)	11 (8, 12)	12 (12, 13)	9 (8, 10)
	n_trt	30 (25, 81)	28 (25, 34)	38 (36, 40)	26 (25, 28)
	n_control	33 (20, 81)	27 (25, 31)	34 (32, 36)	22 (20, 24)
	post_p	0.98 (0.91, 1)	0.88 (0.86, 0.9)	0.91 (0.88, 0.93)	0.95 (0.95, 0.96)
	order	1 (1, 2)	1 (1, 1.6)	1.5 (1.1, 1.9)	1 (1, 1)
TP53+	count	1	12	4	3
	time_stop	7 (7, 7)	11 (8, 16)	12 (10, 14)	11 (9, 18)
	n_trt	25 (25, 25)	32 (25, 52)	34 (25, 43)	28 (26, 43)
	n_control	17 (17, 17)	37 (19, 55)	30 (22, 36)	30 (27, 56)
	post_p	0.86 (0.86, 0.86)	0.98 (0.9, 0.99)	0.94 (0.87, 0.98)	0.93 (0.91, 0.98)
	order	1 (1, 1)	1 (1, 2)	2 (1.3, 2)	1 (1, 1.8)
DRD+	count		3	159	166
	time_stop		13 (11, 14)	20 (13, 32)	20 (12, 32)
	n_trt		25 (25, 27)	38 (26, 73)	34 (25, 71)
	n_control		18 (16, 24)	39 (22, 74)	38 (23, 72)
	post_p		0.92 (0.9, 0.96)	1 (0.97, 1)	1 (0.96, 1)
	order		2 (1.2, 2)	2 (1, 3)	2 (1, 3)
TEfus+	count	1	167	3	1
	time_stop	10 (10, 10)	15 (10, 31)	9 (7, 12)	14 (14, 14)
	n_trt	25 (25, 25)	34 (26, 85)	25 (25, 33)	29 (29, 29)
	n_control	19 (19, 19)	36 (22, 86)	29 (20, 31)	41 (41, 41)
	post_p	0.97 (0.97, 0.97)	0.99 (0.96, 1)	0.94 (0.88, 0.96)	0.99 (0.99, 0.99)
	order	1 (1, 1)	1 (1, 3)	1 (1, 1)	2 (2, 2)

Futility:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	1
	time_stop	4 (4, 4)
	n_trt	30 (30, 30)
	n_control	22 (22, 22)
	post_p	0.14 (0.14, 0.14)
	order	1 (1, 1)
TP53- & AR-	count		105	122	110
	time_stop		14 (9, 24)	13 (9, 23)	13 (9, 21)
	n_trt		36 (26, 70)	32 (26, 67)	32 (25, 61)
	n_control		37 (23, 71)	34 (21, 73)	32 (20, 59)
	post_p		0.04 (0, 0.17)	0.07 (0.01, 0.24)	0.06 (0.01, 0.24)
	order		1 (1, 2)	1 (1, 2)	1 (1, 2)
TP53+	count	254		3	3
	time_stop	18 (10, 32)		13 (12, 15)	11 (9, 13)
	n_trt	56 (28, 99)		39 (39, 41)	38 (29, 39)
	n_control	54 (25, 99)		43 (39, 47)	31 (29, 33)
	post_p	0.02 (0, 0.13)		0.03 (0.03, 0.11)	0.06 (0.06, 0.24)
	order	1 (1, 3)		2 (1.2, 2)	1 (1, 1.8)
DRD+	count	75	7
	time_stop	20 (14, 32)	18 (16, 33)
	n_trt	33 (26, 51)	33 (30, 84)
	n_control	40 (23, 62)	35 (26, 73)
	post_p	0.03 (0, 0.13)	0.07 (0.03, 0.13)
	order	2 (1, 3)	2 (1, 3)
TEfus+	count	93		6	11
	time_stop	22 (11, 35)		12 (12, 28)	19 (10, 25)
	n_trt	47 (26, 83)		34 (29, 77)	39 (25, 54)
	n_control	54 (24, 102)		33 (26, 75)	45 (23, 72)
	post_p	0.01 (0, 0.06)		0.02 (0, 0.09)	0.04 (0.02, 0.09)
	order	2 (1, 3.8)		3 (1.5, 3)	2 (1, 4)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
		time	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)
		n	8 (6, 10)	1 (0, 1)	4 (3, 5)	3 (2, 3)	1 (0, 1)	4 (2, 5)	0 (0, 2)	0 (0, 2)	1 (0, 3)	1 (1, 3)	0 (0, 0)	0 (0, 1)	1 (0, 2)	1 (0, 3)	1 (1, 1)	0 (0, 1)
		post_p	0.73 (0.68, 0.74)	0.5 (0.5, 0.5)	0.67 (0.6, 0.73)	0.6 (0.57, 0.66)	0.57 (0.54, 0.59)	0.52 (0.52, 0.52)	0.5 (0.5, 0.5)	0.58 (0.58, 0.58)	0.52 (0.52, 0.52)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.61 (0.61, 0.61)	0.64 (0.64, 0.64)	0.56 (0.56, 0.56)	NA (NA, NA)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0 (0, 0.073)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.059 (0.012, 0.106)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0.051 (0.01, 0.092)	0 (0, 1.248)	0.291 (0.291, 0.291)
	Niraparib	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)
		n	8 (8, 8)	1 (1, 1)	4 (4, 4)	2 (2, 2)	2 (2, 2)	2 (2, 2)	2 (2, 2)	2 (2, 2)	2 (2, 2)	1 (1, 1)	1 (1, 1)	0 (0, 0)	0 (0, 0)	2 (2, 2)	2 (2, 2)	2 (2, 2)
		post_p	0.67 (0.67, 0.67)	0.68 (0.68, 0.68)	0.57 (0.57, 0.57)	0.58 (0.58, 0.58)	0.55 (0.55, 0.55)	0.5 (0.5, 0.5)	0.52 (0.52, 0.52)	0.52 (0.52, 0.52)	0.6 (0.6, 0.6)	0.61 (0.61, 0.61)	0.6 (0.6, 0.6)	NA (NA, NA)	NA (NA, NA)	0.52 (0.52, 0.52)	0.53 (0.53, 0.53)	0.64 (0.64, 0.64)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.078 (0.078, 0.078)	0 (0, 0)	0.085 (0.085, 0.085)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	Taxel_therapies	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
		time	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)
		n	9 (7, 11)	2 (0, 2)	2 (1, 4)	3 (3, 4)	2 (2, 3)	0 (0, 2)	0 (0, 0)	1 (0, 1)	2 (0, 3)	1 (0, 2)	2 (1, 3)	1 (0, 3)	0 (0, 1)	0 (0, 3)	0 (0, 1)	0 (0, 1)
		post_p	0.65 (0.62, 0.71)	0.56 (0.56, 0.56)	0.63 (0.6, 0.65)	0.68 (0.68, 0.7)	0.56 (0.54, 0.59)	0.6 (0.6, 0.6)	NA (NA, NA)	0.53 (0.53, 0.53)	0.8 (0.76, 0.84)	0.61 (0.61, 0.61)	0.67 (0.63, 0.73)	0.55 (0.55, 0.55)	0.55 (0.55, 0.55)	0.69 (0.69, 0.69)	0.51 (0.51, 0.51)	0.57 (0.57, 0.57)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.075 (0.049, 0.099)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
DRD+	Carboplatin	count					166	166	166	166					166	166	166	166
		time					20 (12, 32)	20 (12, 32)	20 (12, 32)	20 (12, 32)					20 (12, 32)	20 (12, 32)	20 (12, 32)	20 (12, 32)
		n					6 (3, 14)	5 (3, 15)	4 (2, 8)	4 (1, 9)					4 (1, 9)	4 (1, 8)	4 (2, 8)	4 (2, 8)
		post_p					0.76 (0.58, 0.93)	0.71 (0.53, 0.83)	0.78 (0.57, 0.96)	0.71 (0.53, 0.88)					0.79 (0.58, 0.96)	0.7 (0.56, 0.88)	0.78 (0.59, 0.96)	0.72 (0.53, 0.87)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.028 (0, 0.061)	0.021 (0, 0.044)	0.025 (0, 0.066)	0.023 (0, 0.058)					0.025 (0, 0.068)	0.019 (0, 0.056)	0.034 (0, 0.076)	0.024 (0, 0.066)
	Niraparib	count					159	159	159	159					159	159	159	159
		time					20 (13, 32)	20 (13, 32)	20 (13, 32)	20 (13, 32)					20 (13, 32)	20 (13, 32)	20 (13, 32)	20 (13, 32)
		n					7 (3, 14)	7 (3, 16)	4 (1, 8)	4 (1, 9)					4 (2, 8)	4 (1, 8)	5 (1, 8)	4 (2, 8)
		post_p					0.76 (0.57, 0.93)	0.73 (0.53, 0.87)	0.78 (0.55, 0.96)	0.72 (0.53, 0.89)					0.77 (0.57, 0.94)	0.71 (0.54, 0.9)	0.8 (0.58, 0.96)	0.72 (0.53, 0.92)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.029 (0, 0.057)	0.022 (0, 0.041)	0.03 (0, 0.068)	0.022 (0, 0.069)					0.031 (0, 0.076)	0.024 (0, 0.058)	0.029 (0, 0.064)	0.024 (0, 0.055)
	Taxel_therapies	count					3	3	3	3					3	3	3	3
		time					13 (11, 14)	13 (11, 14)	13 (11, 14)	13 (11, 14)					13 (11, 14)	13 (11, 14)	13 (11, 14)	13 (11, 14)
		n					4 (4, 5)	5 (4, 5)	4 (2, 5)	4 (3, 6)					1 (0, 3)	3 (2, 4)	1 (0, 1)	3 (2, 5)
		post_p					0.54 (0.52, 0.55)	0.59 (0.55, 0.68)	0.61 (0.58, 0.67)	0.73 (0.65, 0.79)					0.64 (0.63, 0.64)	0.63 (0.57, 0.65)	0.56 (0.53, 0.58)	0.71 (0.67, 0.71)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.075 (0.058, 0.077)	0 (0, 0.024)	0.044 (0.009, 0.106)	0.043 (0.009, 0.054)					0.029 (0.006, 0.053)	0 (0, 0.081)	0 (0, 0)	0 (0, 0.044)
TEfus+	Carboplatin	count		1		1		1		1		1		1		1		1
		time		14 (14, 14)		14 (14, 14)		14 (14, 14)		14 (14, 14)		14 (14, 14)		14 (14, 14)		14 (14, 14)		14 (14, 14)
		n		3 (3, 3)		5 (5, 5)		5 (5, 5)		3 (3, 3)		5 (5, 5)		1 (1, 1)		3 (3, 3)		4 (4, 4)
		post_p		0.73 (0.73, 0.73)		0.65 (0.65, 0.65)		0.78 (0.78, 0.78)		0.66 (0.66, 0.66)		0.51 (0.51, 0.51)		0.69 (0.69, 0.69)		0.89 (0.89, 0.89)		0.75 (0.75, 0.75)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0 (0, 0)		0.053 (0.053, 0.053)		0 (0, 0)		0 (0, 0)		0.158 (0.158, 0.158)		0 (0, 0)		0 (0, 0)		0 (0, 0)
	Hormone_therapies	count		1		1		1		1		1		1		1		1
		time		10 (10, 10)		10 (10, 10)		10 (10, 10)		10 (10, 10)		10 (10, 10)		10 (10, 10)		10 (10, 10)		10 (10, 10)
		n		3 (3, 3)		5 (5, 5)		8 (8, 8)		1 (1, 1)		4 (4, 4)		4 (4, 4)		0 (0, 0)		0 (0, 0)
		post_p		0.69 (0.69, 0.69)		0.77 (0.77, 0.77)		0.74 (0.74, 0.74)		0.54 (0.54, 0.54)		0.89 (0.89, 0.89)		0.66 (0.66, 0.66)		NA (NA, NA)		NA (NA, NA)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0 (0, 0)		0.043 (0.043, 0.043)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.078 (0.078, 0.078)		NA (NA, NA)		NA (NA, NA)
	Niraparib	count		3		3		3		3		3		3		3		3
		time		9 (7, 12)		9 (7, 12)		9 (7, 12)		9 (7, 12)		9 (7, 12)		9 (7, 12)		9 (7, 12)		9 (7, 12)
		n		2 (1, 4)		11 (9, 13)		4 (3, 5)		2 (1, 3)		2 (1, 3)		3 (1, 4)		2 (2, 3)		2 (2, 3)
		post_p		0.52 (0.51, 0.56)		0.75 (0.72, 0.78)		0.7 (0.61, 0.75)		0.57 (0.56, 0.63)		0.6 (0.57, 0.68)		0.62 (0.53, 0.7)		0.54 (0.52, 0.83)		0.54 (0.53, 0.62)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0 (0, 0.093)		0.082 (0.041, 0.107)		0 (0, 0)		0 (0, 0)		0.093 (0.019, 0.122)		0.031 (0.006, 0.055)		0 (0, 0.03)		0 (0, 0.069)
	Taxel_therapies	count		167		167		167		167		167		167		167		167
		time		15 (10, 31)		15 (10, 31)		15 (10, 31)		15 (10, 31)		15 (10, 31)		15 (10, 31)		15 (10, 31)		15 (10, 31)
		n		5 (2, 13)		10 (5, 22)		5 (2, 12)		3 (1, 9)		4 (1, 9)		4 (2, 10)		3 (1, 7)		3 (1, 8)
		post_p		0.75 (0.57, 0.9)		0.9 (0.73, 0.99)		0.69 (0.53, 0.83)		0.67 (0.52, 0.86)		0.78 (0.6, 0.97)		0.77 (0.57, 0.97)		0.66 (0.53, 0.83)		0.68 (0.52, 0.88)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.026 (0, 0.061)		0.037 (0, 0.069)		0.013 (0, 0.042)		0.008 (0, 0.064)		0.025 (0, 0.08)		0.028 (0, 0.076)		0.017 (0, 0.061)		0.019 (0, 0.063)
TP53- & AR-	Carboplatin	count	2	2			2	2
		time	9 (8, 10)	9 (8, 10)			9 (8, 10)	9 (8, 10)
		n	16 (15, 18)	2 (1, 4)			3 (3, 3)	4 (3, 6)
		post_p	0.81 (0.76, 0.86)	0.63 (0.57, 0.69)			0.61 (0.55, 0.67)	0.78 (0.78, 0.79)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.065 (0.04, 0.09)	0.024 (0.005, 0.043)			0.062 (0.012, 0.112)	0 (0, 0)
	Hormone_therapies	count	272	272			272	272
		time	12 (9, 28)	12 (9, 28)			12 (9, 28)	12 (9, 28)
		n	21 (15, 51)	4 (2, 10)			4 (2, 11)	4 (1, 11)
		post_p	0.96 (0.82, 1)	0.71 (0.54, 0.87)			0.71 (0.54, 0.86)	0.63 (0.52, 0.78)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.039 (0.017, 0.062)	0.027 (0, 0.076)			0.017 (0, 0.064)	0 (0, 0.053)
	Niraparib	count	2	2			2	2
		time	12 (12, 13)	12 (12, 13)			12 (12, 13)	12 (12, 13)
		n	26 (21, 30)	2 (1, 4)			5 (5, 5)	5 (4, 6)
		post_p	0.78 (0.77, 0.79)	0.54 (0.53, 0.55)			0.87 (0.82, 0.91)	0.72 (0.57, 0.87)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.092 (0.076, 0.108)	0.045 (0.009, 0.081)			0 (0, 0)	0 (0, 0)
	Taxel_therapies	count	5	5			5	5
		time	11 (8, 12)	11 (8, 12)			11 (8, 12)	11 (8, 12)
		n	22 (17, 25)	4 (3, 6)			2 (0, 3)	1 (0, 4)
		post_p	0.76 (0.72, 0.8)	0.75 (0.68, 0.87)			0.57 (0.54, 0.66)	0.67 (0.57, 0.75)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.072 (0.059, 0.102)	0 (0, 0.072)			0 (0, 0.027)	0 (0, 0)
TP53+	Carboplatin	count			3	3			3	3			3	3			3	3
		time			11 (9, 18)	11 (9, 18)			11 (9, 18)	11 (9, 18)			11 (9, 18)	11 (9, 18)			11 (9, 18)	11 (9, 18)
		n			14 (7, 16)	4 (3, 5)			3 (2, 3)	1 (0, 6)			3 (2, 5)	1 (0, 3)			3 (1, 5)	5 (3, 5)
		post_p			0.85 (0.57, 0.88)	0.69 (0.62, 0.74)			0.7 (0.56, 0.72)	0.69 (0.6, 0.78)			0.61 (0.58, 0.64)	0.56 (0.55, 0.57)			0.68 (0.55, 0.86)	0.72 (0.68, 0.8)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.136 (0.123, 0.142)	0 (0, 0.066)			0 (0, 0.047)	0 (0, 0)			0.067 (0.013, 0.145)	0.035 (0.007, 0.063)			0 (0, 0.03)	0 (0, 0.016)
	Hormone_therapies	count			1	1			1	1			1	1			1	1
		time			7 (7, 7)	7 (7, 7)			7 (7, 7)	7 (7, 7)			7 (7, 7)	7 (7, 7)			7 (7, 7)	7 (7, 7)
		n			6 (6, 6)	6 (6, 6)			1 (1, 1)	1 (1, 1)			1 (1, 1)	1 (1, 1)			2 (2, 2)	7 (7, 7)
		post_p			0.87 (0.87, 0.87)	0.76 (0.76, 0.76)			0.53 (0.53, 0.53)	NA (NA, NA)			0.51 (0.51, 0.51)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.08 (0.08, 0.08)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0 (0, 0)	1.02 (1.02, 1.02)			0.167 (0.167, 0.167)	0.055 (0.055, 0.055)
	Niraparib	count			4	4			4	4			4	4			4	4
		time			12 (10, 14)	12 (10, 14)			12 (10, 14)	12 (10, 14)			12 (10, 14)	12 (10, 14)			12 (10, 14)	12 (10, 14)
		n			12 (11, 14)	8 (5, 10)			2 (1, 4)	2 (1, 4)			2 (0, 4)	2 (2, 4)			2 (1, 3)	2 (1, 4)
		post_p			0.76 (0.74, 0.85)	0.72 (0.66, 0.73)			0.7 (0.56, 0.79)	0.57 (0.5, 0.68)			0.6 (0.52, 0.67)	0.68 (0.57, 0.77)			0.74 (0.58, 0.86)	0.56 (0.53, 0.68)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.105 (0.078, 0.131)	0.08 (0.057, 0.126)			0.029 (0, 0.06)	0 (0, 0.025)			0.122 (0.076, 0.168)	0.056 (0.016, 0.065)			0 (0, 0)	0.027 (0.005, 0.033)
	Taxel_therapies	count			12	12			12	12			12	12			12	12
		time			11 (8, 16)	11 (8, 16)			11 (8, 16)	11 (8, 16)			11 (8, 16)	11 (8, 16)			11 (8, 16)	11 (8, 16)
		n			10 (6, 18)	8 (5, 12)			2 (1, 3)	3 (1, 5)			3 (1, 4)	3 (1, 7)			2 (0, 3)	2 (0, 5)
		post_p			0.78 (0.71, 0.9)	0.83 (0.73, 0.93)			0.58 (0.51, 0.7)	0.68 (0.52, 0.76)			0.64 (0.55, 0.83)	0.72 (0.57, 0.85)			0.53 (0.5, 0.7)	0.54 (0.52, 0.59)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.101 (0.08, 0.149)	0.034 (0, 0.057)			0.025 (0, 0.166)	0 (0, 0.073)			0.091 (0.046, 0.125)	0.01 (0, 0.068)			0 (0, 0.101)	0 (0, 0.068)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)
		n	6 (6, 6)	1 (1, 1)	2 (2, 2)	4 (4, 4)	0 (0, 0)	2 (2, 2)	1 (1, 1)	2 (2, 2)	3 (3, 3)	4 (4, 4)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (2, 2)	2 (2, 2)
		post_p	0.44 (0.44, 0.44)	0.46 (0.46, 0.46)	0.35 (0.35, 0.35)	NA (NA, NA)	NA (NA, NA)	0.25 (0.25, 0.25)	NA (NA, NA)	0.37 (0.37, 0.37)	NA (NA, NA)	NA (NA, NA)	0.28 (0.28, 0.28)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.36 (0.36, 0.36)	NA (NA, NA)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.182 (0.182, 0.182)	0 (0, 0)	0.327 (0.327, 0.327)	0 (0, 0)	NA (NA, NA)	0.194 (0.194, 0.194)	0 (0, 0)	0.246 (0.246, 0.246)	0.348 (0.348, 0.348)	0 (0, 0)	3.745 (3.745, 3.745)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.274 (0.274, 0.274)	0.489 (0.489, 0.489)
DRD+		count					75	75	75	75					75	75	75	75
		time					20 (14, 32)	20 (14, 32)	20 (14, 32)	20 (14, 32)					20 (14, 32)	20 (14, 32)	20 (14, 32)	20 (14, 32)
		n					5 (2, 10)	5 (2, 12)	4 (2, 7)	4 (1, 7)					4 (1, 8)	4 (1, 9)	4 (1, 7)	3 (1, 8)
		post_p					0.4 (0.21, 0.49)	0.37 (0.18, 0.48)	0.3 (0.15, 0.47)	0.21 (0.07, 0.36)					0.29 (0.13, 0.48)	0.27 (0.08, 0.45)	0.3 (0.09, 0.44)	0.25 (0.07, 0.45)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.086 (0.056, 0.146)	0.057 (0.036, 0.117)	0.2 (0.114, 0.413)	0.173 (0.093, 0.72)					0.183 (0.113, 0.393)	0.147 (0.081, 0.38)	0.199 (0.087, 0.406)	0.182 (0.078, 0.45)
	Taxel_therapies	count					7	7	7	7					7	7	7	7
		time					18 (16, 33)	18 (16, 33)	18 (16, 33)	18 (16, 33)					18 (16, 33)	18 (16, 33)	18 (16, 33)	18 (16, 33)
		n					6 (5, 17)	8 (7, 17)	2 (1, 9)	5 (2, 10)					5 (4, 10)	3 (0, 6)	6 (4, 8)	4 (1, 8)
		post_p					0.17 (0.05, 0.38)	0.38 (0.28, 0.42)	0.29 (0.18, 0.4)	0.39 (0.22, 0.47)					0.15 (0.09, 0.27)	0.34 (0.25, 0.36)	0.39 (0.26, 0.47)	0.36 (0.2, 0.44)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.118 (0.069, 0.204)	0.049 (0.045, 0.083)	0.191 (0.161, 1.214)	0.078 (0.058, 0.323)					0.194 (0.153, 0.424)	0.125 (0.062, 1.455)	0.131 (0.116, 0.18)	0.105 (0.04, 0.159)
TEfus+	Carboplatin	count		6		6		6		6		6		6		6		6
		time		12 (12, 28)		12 (12, 28)		12 (12, 28)		12 (12, 28)		12 (12, 28)		12 (12, 28)		12 (12, 28)		12 (12, 28)
		n		5 (4, 11)		7 (5, 21)		5 (4, 12)		4 (2, 5)		6 (2, 10)		6 (2, 10)		2 (0, 8)		2 (1, 4)
		post_p		0.22 (0.1, 0.36)		0.26 (0.06, 0.39)		0.36 (0.21, 0.46)		0.38 (0.3, 0.42)		0.27 (0.1, 0.43)		0.25 (0.12, 0.31)		0.36 (0.18, 0.41)		0.45 (0.24, 0.48)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.19 (0.119, 0.566)		0.167 (0.147, 0.291)		0.056 (0.039, 0.078)		0.071 (0.038, 0.087)		0.21 (0.17, 0.334)		0.182 (0.153, 0.517)		0.143 (0.076, 0.537)		0.067 (0.025, 0.332)
	Hormone_therapies	count		93		93		93		93		93		93		93		93
		time		22 (11, 35)		22 (11, 35)		22 (11, 35)		22 (11, 35)		22 (11, 35)		22 (11, 35)		22 (11, 35)		22 (11, 35)
		n		5 (2, 12)		12 (6, 24)		5 (2, 12)		4 (1, 9)		6 (3, 10)		5 (2, 10)		4 (2, 9)		4 (2, 9)
		post_p		0.42 (0.29, 0.49)		0.21 (0.04, 0.39)		0.39 (0.18, 0.49)		0.24 (0.07, 0.4)		0.29 (0.08, 0.47)		0.3 (0.09, 0.44)		0.24 (0.07, 0.45)		0.23 (0.06, 0.43)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.086 (0.055, 0.154)		0.163 (0.117, 0.238)		0.06 (0.032, 0.129)		0.168 (0.08, 0.43)		0.181 (0.104, 0.445)		0.185 (0.1, 0.398)		0.167 (0.073, 0.412)		0.146 (0.079, 0.489)
	Niraparib	count		11		11		11		11		11		11		11		11
		time		19 (10, 25)		19 (10, 25)		19 (10, 25)		19 (10, 25)		19 (10, 25)		19 (10, 25)		19 (10, 25)		19 (10, 25)
		n		5 (2, 7)		12 (7, 21)		5 (0, 9)		2 (0, 4)		6 (4, 10)		4 (3, 5)		2 (0, 7)		2 (1, 8)
		post_p		0.25 (0.05, 0.4)		0.21 (0.11, 0.43)		0.39 (0.24, 0.48)		0.41 (0.28, 0.5)		0.32 (0.24, 0.42)		0.34 (0.24, 0.45)		0.46 (0.44, 0.49)		0.35 (0.27, 0.45)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.189 (0.127, 0.526)		0.171 (0.113, 0.262)		0.067 (0.027, 0.084)		0.103 (0.042, 0.24)		0.18 (0.134, 0.397)		0.179 (0.115, 0.328)		0.071 (0.029, 0.918)		0.111 (0.077, 0.239)
TP53- & AR-	Carboplatin	count	122	122			122	122
		time	13 (9, 23)	13 (9, 23)			13 (9, 23)	13 (9, 23)
		n	22 (15, 43)	4 (2, 10)			4 (2, 9)	5 (2, 9)
		post_p	0.13 (0.01, 0.36)	0.28 (0.06, 0.46)			0.45 (0.34, 0.49)	0.4 (0.23, 0.49)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.161 (0.121, 0.212)	0.164 (0.071, 0.384)			0.083 (0.042, 0.195)	0.06 (0.026, 0.147)
	Niraparib	count	110	110			110	110
		time	13 (9, 21)	13 (9, 21)			13 (9, 21)	13 (9, 21)
		n	21 (15, 38)	5 (2, 9)			4 (1, 9)	4 (2, 9)
		post_p	0.16 (0.02, 0.43)	0.26 (0.05, 0.45)			0.42 (0.26, 0.49)	0.4 (0.25, 0.49)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.152 (0.116, 0.208)	0.167 (0.087, 0.396)			0.082 (0.047, 0.182)	0.063 (0.022, 0.207)
	Taxel_therapies	count	105	105			105	105
		time	14 (9, 24)	14 (9, 24)			14 (9, 24)	14 (9, 24)
		n	24 (15, 42)	4 (1, 8)			5 (2, 10)	5 (2, 10)
		post_p	0.09 (0, 0.33)	0.45 (0.34, 0.49)			0.25 (0.05, 0.44)	0.4 (0.24, 0.48)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.156 (0.123, 0.224)	0.095 (0.045, 0.213)			0.155 (0.085, 0.315)	0.058 (0.03, 0.146)
TP53+	Carboplatin	count			3	3			3	3			3	3			3	3
		time			13 (12, 15)	13 (12, 15)			13 (12, 15)	13 (12, 15)			13 (12, 15)	13 (12, 15)			13 (12, 15)	13 (12, 15)
		n			13 (12, 22)	5 (4, 11)			0 (0, 2)	2 (2, 4)			4 (2, 6)	4 (4, 6)			1 (0, 1)	3 (1, 5)
		post_p			0.28 (0.1, 0.28)	0.2 (0.11, 0.23)			0.46 (0.46, 0.46)	0.48 (0.35, 0.49)			0.39 (0.16, 0.39)	0.25 (0.19, 0.31)			0.44 (0.39, 0.49)	0.47 (0.46, 0.47)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.168 (0.155, 0.328)	0.192 (0.158, 0.232)			0.13 (0.13, 0.13)	0.027 (0.005, 0.072)			0.374 (0.246, 0.516)	0.221 (0.183, 0.316)			0.082 (0.016, 0.147)	0.049 (0.01, 0.058)
	Hormone_therapies	count			254	254			254	254			254	254			254	254
		time			18 (10, 32)	18 (10, 32)			18 (10, 32)	18 (10, 32)			18 (10, 32)	18 (10, 32)			18 (10, 32)	18 (10, 32)
		n			18 (8, 35)	11 (6, 23)			4 (1, 8)	4 (1, 8)			5 (1, 10)	5 (2, 10)			4 (1, 8)	4 (1, 8)
		post_p			0.34 (0.1, 0.48)	0.19 (0.03, 0.42)			0.33 (0.12, 0.48)	0.24 (0.08, 0.45)			0.37 (0.19, 0.48)	0.33 (0.12, 0.47)			0.27 (0.09, 0.46)	0.25 (0.07, 0.43)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.178 (0.14, 0.263)	0.163 (0.113, 0.266)			0.174 (0.101, 0.434)	0.165 (0.076, 0.466)			0.201 (0.138, 0.443)	0.175 (0.098, 0.376)			0.19 (0.097, 0.467)	0.178 (0.086, 0.435)
	Niraparib	count			3	3			3	3			3	3			3	3
		time			11 (9, 13)	11 (9, 13)			11 (9, 13)	11 (9, 13)			11 (9, 13)	11 (9, 13)			11 (9, 13)	11 (9, 13)
		n			10 (9, 15)	10 (8, 12)			2 (0, 3)	3 (2, 4)			2 (2, 3)	3 (1, 5)			1 (0, 1)	3 (1, 4)
		post_p			0.4 (0.19, 0.45)	0.21 (0.11, 0.32)			0.44 (0.4, 0.48)	0.28 (0.25, 0.4)			0.37 (0.36, 0.39)	0.41 (0.34, 0.44)			0.48 (0.46, 0.49)	0.42 (0.42, 0.43)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.199 (0.159, 0.262)	0.188 (0.18, 0.214)			0.077 (0.049, 0.104)	0.178 (0.134, 0.245)			0.164 (0.144, 0.268)	0.125 (0.124, 0.336)			0.11 (0.022, 0.198)	0.085 (0.078, 0.093)