Equal randomization: several treatments more effective in distinctive signatures (cfr scen 7)
By subgroup:
| subtype | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.112, shape = 1.05 | scale = 0.043, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 22.6, median = 16.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 2.58, hr = 0.37 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| —+ | param | scale = 0.112, shape = 1.05 | scale = 0.043, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 22.6, median = 16.3 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 2.58, hr = 0.37 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| –+- | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| –++ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| -+– | param | scale = 0.112, shape = 1.05 | scale = 0.043, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 22.6, median = 16.3 | mean = 6.3, median = 4.5 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 2.58, hr = 0.37 | af = 0.71, hr = 1.43 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.043, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 22.6, median = 16.3 | mean = 25, median = 18 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 2.58, hr = 0.37 | af = 2.85, hr = 0.33 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -++- | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -+++ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| +— | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| +–+ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| +-+- | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| +-++ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| ++– | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| ++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| +++- | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| ++++ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 |
By signature:
| signature | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| all | param | scale = 0.112, shape = 1.05 | scale = 0.129, shape = 1.05 | scale = 0.099, shape = 1.05 | scale = 0.098, shape = 1.05 | scale = 0.098, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 7.6, median = 5.5 | mean = 9.9, median = 7.1 | mean = 10, median = 7.2 | mean = 10, median = 7.2 | |
| effect | af = 1, hr = 1 | af = 0.87, hr = 1.16 | af = 1.13, hr = 0.88 | af = 1.14, hr = 0.87 | af = 1.14, hr = 0.87 | |
| TP53- & AR- | param | scale = 0.112, shape = 1.05 | scale = 0.043, shape = 1.05 | scale = 0.099, shape = 1.05 | scale = 0.098, shape = 1.05 | scale = 0.098, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 22.6, median = 16.3 | mean = 9.9, median = 7.1 | mean = 10, median = 7.2 | mean = 10, median = 7.2 | |
| effect | af = 1, hr = 1 | af = 2.58, hr = 0.37 | af = 1.13, hr = 0.88 | af = 1.14, hr = 0.87 | af = 1.14, hr = 0.87 | |
| TP53+ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.099, shape = 1.05 | scale = 0.098, shape = 1.05 | scale = 0.098, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 9.9, median = 7.1 | mean = 10, median = 7.2 | mean = 10, median = 7.2 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 1.13, hr = 0.88 | af = 1.14, hr = 0.87 | af = 1.14, hr = 0.87 | |
| DRD+ | param | scale = 0.112, shape = 1.05 | scale = 0.129, shape = 1.05 | scale = 0.099, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 7.6, median = 5.5 | mean = 9.9, median = 7.1 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.87, hr = 1.16 | af = 1.13, hr = 0.88 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| TEfus+ | param | scale = 0.112, shape = 1.05 | scale = 0.129, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.098, shape = 1.05 | scale = 0.098, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 7.6, median = 5.5 | mean = 25, median = 18 | mean = 10, median = 7.2 | mean = 10, median = 7.2 | |
| effect | af = 1, hr = 1 | af = 0.87, hr = 1.16 | af = 2.85, hr = 0.33 | af = 1.14, hr = 0.87 | af = 1.14, hr = 0.87 |
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The overall error was 0.048.
The corresponding errors separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.008 0.026 0.006 0.008
The overall power was 0.858.
The corresponding power separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.544 0.334 0.332 0.318
| signature | var | Carboplatin | Control | Hormone_therapies | Niraparib | Taxel_therapies |
|---|---|---|---|---|---|---|
| all | graduation | 0 | 0 | 3 | 1 | 3 |
| futility | 0 | 0 | 1 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 248 (180, 292) | 276 (244, 311) | 186 (121, 253) | 244 (182, 292) | 236 (177, 287) | |
| n_unique | 225 (164, 266) | 252 (226, 284) | 167 (106, 230) | 221 (165, 268) | 216 (160, 262) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | NA (NA, NA) | NA (NA, NA) | 4 (4, 4) | 5 (5, 5) | 4 (4, 5) | |
| post_p | 0.24 (0.01, 0.71) | NA (NA, NA) | 0.47 (0.02, 0.98) | 0.23 (0.01, 0.71) | 0.53 (0.06, 0.94) | |
| rate | 0.1 (0.09, 0.115) | 0.093 (0.084, 0.102) | 0.092 (0.075, 0.115) | 0.101 (0.09, 0.114) | 0.092 (0.079, 0.109) | |
| DRD+ | graduation | 166 | 0 | 0 | 159 | 3 |
| futility | 0 | 0 | 75 | 0 | 7 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 67 (28, 90) | 82 (67, 99) | 52 (31, 77) | 67 (30, 89) | 68 (45, 93) | |
| n_unique | 60 (25, 81) | 76 (61, 92) | 46 (27, 71) | 61 (27, 80) | 60 (40, 83) | |
| time_trial | 36 (16, 36) | 36 (36, 36) | 36 (22, 36) | 36 (16, 36) | 36 (36, 36) | |
| time_stop | 20 (12, 32) | NA (NA, NA) | 20 (14, 32) | 20 (13, 32) | 17 (13, 33) | |
| post_p | 1 (0.99, 1) | NA (NA, NA) | 0.15 (0.01, 0.64) | 1 (0.99, 1) | 0.52 (0.12, 0.92) | |
| rate | 0.036 (0.027, 0.044) | 0.089 (0.074, 0.107) | 0.099 (0.076, 0.135) | 0.035 (0.027, 0.044) | 0.079 (0.061, 0.1) | |
| TEfus+ | graduation | 1 | 0 | 1 | 3 | 167 |
| futility | 6 | 0 | 93 | 11 | 0 | |
| max_n | 0 | 0 | 0 | 2 | 1 | |
| n | 94 (69, 119) | 105 (87, 124) | 70 (36, 101) | 91 (69, 118) | 86 (28, 114) | |
| n_unique | 85 (63, 107) | 96 (80, 114) | 63 (32, 89) | 83 (62, 107) | 77 (25, 101) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (22, 36) | 36 (36, 36) | 36 (12, 36) | |
| time_stop | 13 (12, 26) | NA (NA, NA) | 22 (11, 35) | 16 (9, 24) | 15 (10, 31) | |
| post_p | 0.16 (0.01, 0.55) | NA (NA, NA) | 0.02 (0, 0.23) | 0.17 (0.02, 0.55) | 1 (0.98, 1) | |
| rate | 0.09 (0.073, 0.109) | 0.074 (0.063, 0.086) | 0.11 (0.086, 0.139) | 0.088 (0.073, 0.107) | 0.038 (0.03, 0.046) | |
| TP53- & AR- | graduation | 2 | 0 | 272 | 2 | 5 |
| futility | 122 | 0 | 0 | 110 | 105 | |
| max_n | 14 | 0 | 8 | 17 | 11 | |
| n | 100 (30, 130) | 115 (96, 143) | 73 (26, 116) | 100 (31, 129) | 100 (32, 131) | |
| n_unique | 92 (28, 117) | 106 (88, 133) | 68 (24, 106) | 91 (28, 118) | 92 (29, 120) | |
| time_trial | 36 (12, 36) | 36 (36, 36) | 29 (9, 36) | 36 (12, 36) | 36 (13, 36) | |
| time_stop | 13 (9, 23) | NA (NA, NA) | 12 (9, 28) | 13 (9, 21) | 13 (9, 23) | |
| post_p | 0.02 (0, 0.24) | NA (NA, NA) | 1 (0.93, 1) | 0.02 (0, 0.2) | 0.02 (0, 0.2) | |
| rate | 0.106 (0.088, 0.128) | 0.073 (0.062, 0.085) | 0.042 (0.034, 0.051) | 0.105 (0.09, 0.13) | 0.109 (0.09, 0.134) | |
| TP53+ | graduation | 3 | 0 | 1 | 4 | 12 |
| futility | 3 | 0 | 254 | 3 | 0 | |
| max_n | 14 | 0 | 1 | 13 | 9 | |
| n | 114 (90, 137) | 119 (103, 138) | 89 (33, 119) | 113 (91, 136) | 108 (78, 133) | |
| n_unique | 104 (82, 124) | 108 (93, 127) | 81 (30, 108) | 102 (82, 124) | 97 (72, 120) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 35 (12, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | 12 (10, 18) | NA (NA, NA) | 18 (10, 32) | 11 (9, 14) | 11 (8, 16) | |
| post_p | 0.7 (0.22, 0.97) | NA (NA, NA) | 0.02 (0, 0.13) | 0.69 (0.22, 0.97) | 0.96 (0.63, 1) | |
| rate | 0.103 (0.088, 0.12) | 0.112 (0.098, 0.129) | 0.162 (0.138, 0.194) | 0.103 (0.088, 0.123) | 0.084 (0.069, 0.105) |
| subtype | var | Carboplatin | Control | Hormone_therapies | Niraparib | Taxel_therapies |
|---|---|---|---|---|---|---|
| —- | graduation | 124 | 0 | 276 | 113 | 113 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 14 | 0 | 8 | 17 | 11 | |
| n | 62 (19, 81) | 70 (55, 88) | 47 (16, 72) | 63 (20, 81) | 62 (22, 83) | |
| n_unique | 58 (18, 76) | 64 (50, 84) | 44 (15, 68) | 59 (19, 75) | 58 (21, 78) | |
| post_p | 0 (0, 0.06) | NA (NA, NA) | 1 (0.96, 1) | 0 (0, 0.05) | 0 (0, 0.06) | |
| rate | 0.158 (0.132, 0.193) | 0.083 (0.067, 0.101) | 0.043 (0.032, 0.056) | 0.161 (0.135, 0.191) | 0.158 (0.132, 0.193) | |
| —+ | graduation | 128 | 0 | 343 | 122 | 256 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 14 | 0 | 8 | 17 | 12 | |
| n | 14 (4, 20) | 15 (10, 22) | 7 (2, 17) | 13 (4, 21) | 10 (2, 18) | |
| n_unique | 12 (3, 18) | 14 (9, 20) | 6 (2, 15) | 12 (4, 19) | 9 (2, 17) | |
| post_p | 0.04 (0, 0.23) | NA (NA, NA) | 0.75 (0.41, 0.96) | 0.05 (0, 0.25) | 0.83 (0.43, 0.97) | |
| rate | 0.161 (0.109, 0.266) | 0.051 (0.03, 0.081) | 0.044 (0.021, 0.08) | 0.159 (0.105, 0.261) | 0.038 (0.02, 0.075) | |
| –+- | graduation | 6 | 0 | 259 | 8 | 15 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 14 | 0 | 1 | 13 | 9 | |
| n | 37 (28, 46) | 38 (29, 46) | 29 (10, 41) | 38 (28, 47) | 37 (28, 46) | |
| n_unique | 34 (26, 43) | 34 (26, 43) | 27 (10, 37) | 34 (26, 43) | 34 (25, 42) | |
| post_p | 0.4 (0.07, 0.82) | NA (NA, NA) | 0.4 (0.09, 0.78) | 0.37 (0.07, 0.8) | 0.38 (0.07, 0.79) | |
| rate | 0.159 (0.128, 0.206) | 0.146 (0.115, 0.181) | 0.163 (0.127, 0.224) | 0.163 (0.128, 0.206) | 0.161 (0.129, 0.202) | |
| –++ | graduation | 12 | 0 | 305 | 22 | 177 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 14 | 0 | 1 | 14 | 10 | |
| n | 27 (19, 35) | 26 (19, 34) | 18 (7, 30) | 26 (18, 34) | 22 (8, 31) | |
| n_unique | 24 (17, 33) | 24 (17, 32) | 16 (6, 27) | 24 (17, 31) | 20 (7, 28) | |
| post_p | 0.05 (0, 0.27) | NA (NA, NA) | 0.08 (0.01, 0.32) | 0.06 (0, 0.27) | 0.99 (0.9, 1) | |
| rate | 0.156 (0.121, 0.201) | 0.085 (0.059, 0.122) | 0.161 (0.12, 0.23) | 0.158 (0.119, 0.206) | 0.039 (0.022, 0.055) | |
| -+– | graduation | 252 | 0 | 328 | 249 | 122 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 11 | 0 | 8 | 17 | 11 | |
| n | 10 (3, 18) | 15 (9, 21) | 7 (2, 17) | 10 (3, 19) | 13 (4, 20) | |
| n_unique | 9 (3, 16) | 14 (8, 20) | 6 (2, 15) | 10 (3, 17) | 12 (4, 18) | |
| post_p | 0.86 (0.51, 0.98) | NA (NA, NA) | 0.77 (0.43, 0.93) | 0.85 (0.53, 0.98) | 0.05 (0, 0.26) | |
| rate | 0.035 (0.018, 0.069) | 0.08 (0.053, 0.125) | 0.043 (0.021, 0.081) | 0.037 (0.02, 0.067) | 0.162 (0.104, 0.228) | |
| -+-+ | graduation | 255 | 0 | 376 | 255 | 262 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 11 | 0 | 8 | 17 | 12 | |
| n | 10 (3, 21) | 16 (10, 23) | 6 (2, 18) | 11 (3, 20) | 10 (3, 20) | |
| n_unique | 9 (3, 18) | 15 (9, 21) | 5 (2, 15) | 10 (3, 18) | 9 (2, 18) | |
| post_p | 0.63 (0.28, 0.88) | NA (NA, NA) | 0.55 (0.25, 0.81) | 0.63 (0.3, 0.88) | 0.58 (0.26, 0.88) | |
| rate | 0.037 (0.018, 0.066) | 0.053 (0.032, 0.079) | 0.042 (0.018, 0.079) | 0.036 (0.018, 0.064) | 0.039 (0.018, 0.069) | |
| -++- | graduation | 170 | 0 | 294 | 164 | 25 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 14 | 0 | 1 | 11 | 9 | |
| n | 7 (3, 11) | 8 (4, 12) | 5 (2, 11) | 7 (3, 12) | 8 (4, 13) | |
| n_unique | 6 (2, 11) | 7 (4, 11) | 5 (1, 10) | 6 (2, 11) | 7 (3, 11) | |
| post_p | 0.93 (0.69, 0.99) | NA (NA, NA) | 0.28 (0.09, 0.55) | 0.92 (0.69, 0.99) | 0.25 (0.04, 0.53) | |
| rate | 0.034 (0.013, 0.07) | 0.151 (0.087, 0.267) | 0.168 (0.101, 0.36) | 0.035 (0.015, 0.071) | 0.167 (0.094, 0.283) | |
| -+++ | graduation | 175 | 0 | 329 | 175 | 184 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 14 | 0 | 1 | 12 | 10 | |
| n | 7 (3, 12) | 9 (5, 13) | 5 (1, 10) | 7 (2, 12) | 7 (2, 12) | |
| n_unique | 6 (2, 11) | 8 (5, 13) | 4 (1, 9) | 6 (2, 11) | 6 (2, 11) | |
| post_p | 0.76 (0.46, 0.93) | NA (NA, NA) | 0.16 (0.03, 0.38) | 0.76 (0.45, 0.94) | 0.73 (0.46, 0.93) | |
| rate | 0.034 (0.013, 0.072) | 0.087 (0.044, 0.158) | 0.164 (0.097, 0.378) | 0.035 (0.013, 0.078) | 0.038 (0.015, 0.077) | |
| +— | graduation | 0 | 0 | 4 | 1 | 3 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 12 (8, 17) | 12 (7, 17) | 12 (7, 16) | 12 (8, 17) | 12 (8, 17) | |
| n_unique | 11 (7, 15) | 11 (6, 15) | 10 (6, 15) | 11 (7, 16) | 11 (7, 16) | |
| post_p | 0.47 (0.14, 0.82) | NA (NA, NA) | 0.42 (0.12, 0.81) | 0.46 (0.12, 0.8) | 0.47 (0.12, 0.84) | |
| rate | 0.155 (0.104, 0.24) | 0.145 (0.093, 0.222) | 0.166 (0.112, 0.257) | 0.161 (0.11, 0.252) | 0.16 (0.106, 0.254) | |
| +–+ | graduation | 7 | 0 | 98 | 15 | 170 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 2 | 1 | |
| n | 10 (6, 15) | 10 (6, 15) | 9 (4, 15) | 10 (6, 14) | 8 (3, 14) | |
| n_unique | 9 (5, 14) | 9 (6, 14) | 8 (4, 13) | 9 (5, 13) | 7 (2, 12) | |
| post_p | 0.2 (0.03, 0.51) | NA (NA, NA) | 0.21 (0.04, 0.53) | 0.2 (0.04, 0.52) | 0.94 (0.67, 1) | |
| rate | 0.163 (0.106, 0.255) | 0.087 (0.048, 0.153) | 0.166 (0.102, 0.278) | 0.168 (0.107, 0.267) | 0.038 (0.017, 0.076) | |
| +-+- | graduation | 6 | 0 | 259 | 8 | 15 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 14 | 0 | 1 | 13 | 9 | |
| n | 10 (6, 15) | 10 (6, 15) | 8 (2, 13) | 10 (5, 14) | 10 (6, 14) | |
| n_unique | 9 (5, 13) | 9 (5, 13) | 6 (2, 11) | 9 (5, 13) | 9 (5, 13) | |
| post_p | 0.46 (0.15, 0.8) | NA (NA, NA) | 0.42 (0.17, 0.76) | 0.47 (0.16, 0.81) | 0.48 (0.16, 0.81) | |
| rate | 0.16 (0.105, 0.268) | 0.151 (0.095, 0.236) | 0.175 (0.115, 0.34) | 0.16 (0.107, 0.261) | 0.157 (0.104, 0.249) | |
| +-++ | graduation | 12 | 0 | 305 | 22 | 177 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 14 | 0 | 1 | 14 | 10 | |
| n | 11 (7, 16) | 11 (7, 16) | 7 (2, 12) | 10 (6, 16) | 8 (3, 14) | |
| n_unique | 10 (6, 14) | 10 (6, 14) | 6 (2, 12) | 9 (5, 14) | 7 (2, 13) | |
| post_p | 0.19 (0.04, 0.49) | NA (NA, NA) | 0.24 (0.06, 0.5) | 0.19 (0.04, 0.49) | 0.94 (0.66, 0.99) | |
| rate | 0.16 (0.109, 0.253) | 0.087 (0.05, 0.152) | 0.173 (0.107, 0.336) | 0.164 (0.107, 0.262) | 0.039 (0.018, 0.078) | |
| ++– | graduation | 166 | 0 | 79 | 160 | 13 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 6 (3, 11) | 8 (5, 12) | 7 (4, 12) | 6 (3, 11) | 8 (4, 12) | |
| n_unique | 6 (2, 10) | 7 (4, 11) | 7 (3, 11) | 6 (2, 10) | 7 (4, 11) | |
| post_p | 0.92 (0.67, 0.99) | NA (NA, NA) | 0.24 (0.07, 0.5) | 0.91 (0.69, 0.99) | 0.24 (0.07, 0.57) | |
| rate | 0.035 (0.013, 0.077) | 0.152 (0.09, 0.261) | 0.167 (0.1, 0.311) | 0.036 (0.015, 0.073) | 0.158 (0.095, 0.293) | |
| ++-+ | graduation | 172 | 0 | 147 | 171 | 177 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 2 | 1 | |
| n | 7 (2, 11) | 8 (5, 13) | 7 (3, 11) | 7 (2, 12) | 7 (2, 12) | |
| n_unique | 6 (2, 10) | 8 (4, 12) | 6 (2, 10) | 6 (2, 11) | 6 (2, 11) | |
| post_p | 0.76 (0.48, 0.94) | NA (NA, NA) | 0.13 (0.02, 0.34) | 0.78 (0.45, 0.94) | 0.76 (0.44, 0.93) | |
| rate | 0.035 (0.014, 0.069) | 0.089 (0.044, 0.169) | 0.166 (0.099, 0.304) | 0.036 (0.014, 0.073) | 0.037 (0.017, 0.08) | |
| +++- | graduation | 170 | 0 | 294 | 164 | 25 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 14 | 0 | 1 | 11 | 9 | |
| n | 7 (3, 11) | 8 (5, 13) | 5 (2, 10) | 7 (3, 12) | 8 (4, 13) | |
| n_unique | 6 (2, 10) | 8 (4, 12) | 5 (1, 9) | 6 (2, 11) | 7 (3, 11) | |
| post_p | 0.92 (0.69, 0.99) | NA (NA, NA) | 0.27 (0.09, 0.53) | 0.93 (0.72, 0.99) | 0.24 (0.06, 0.58) | |
| rate | 0.035 (0.015, 0.069) | 0.153 (0.088, 0.265) | 0.173 (0.101, 0.343) | 0.034 (0.012, 0.069) | 0.159 (0.096, 0.268) | |
| ++++ | graduation | 175 | 0 | 329 | 175 | 184 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 14 | 0 | 1 | 12 | 10 | |
| n | 7 (3, 13) | 9 (5, 13) | 5 (2, 10) | 7 (3, 12) | 7 (2, 12) | |
| n_unique | 6 (2, 11) | 8 (4, 12) | 5 (1, 9) | 6 (2, 11) | 6 (2, 11) | |
| post_p | 0.78 (0.46, 0.95) | NA (NA, NA) | 0.17 (0.03, 0.36) | 0.78 (0.46, 0.95) | 0.75 (0.44, 0.93) | |
| rate | 0.034 (0.013, 0.074) | 0.094 (0.047, 0.181) | 0.173 (0.093, 0.373) | 0.034 (0.013, 0.069) | 0.04 (0.015, 0.078) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | Hormone_therapies | Taxel_therapies | Niraparib | Carboplatin |
|---|---|---|---|---|---|
| all | count | 3 | 3 | 1 | |
| time_stop | 4 (4, 4) | 4 (4, 5) | 5 (5, 5) | ||
| n_trt | 28 (26, 29) | 27 (25, 32) | 33 (33, 33) | ||
| n_control | 24 (22, 30) | 24 (17, 35) | 23 (23, 23) | ||
| post_p | 0.9 (0.86, 0.91) | 0.97 (0.92, 0.97) | 0.9 (0.9, 0.9) | ||
| order | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | ||
| TP53- & AR- | count | 272 | 5 | 2 | 2 |
| time_stop | 12 (9, 28) | 11 (8, 12) | 12 (12, 13) | 9 (8, 10) | |
| n_trt | 30 (25, 81) | 28 (25, 34) | 38 (36, 40) | 26 (25, 28) | |
| n_control | 33 (20, 81) | 27 (25, 31) | 34 (32, 36) | 22 (20, 24) | |
| post_p | 0.98 (0.91, 1) | 0.88 (0.86, 0.9) | 0.91 (0.88, 0.93) | 0.95 (0.95, 0.96) | |
| order | 1 (1, 2) | 1 (1, 1.6) | 1.5 (1.1, 1.9) | 1 (1, 1) | |
| TP53+ | count | 1 | 12 | 4 | 3 |
| time_stop | 7 (7, 7) | 11 (8, 16) | 12 (10, 14) | 11 (9, 18) | |
| n_trt | 25 (25, 25) | 32 (25, 52) | 34 (25, 43) | 28 (26, 43) | |
| n_control | 17 (17, 17) | 37 (19, 55) | 30 (22, 36) | 30 (27, 56) | |
| post_p | 0.86 (0.86, 0.86) | 0.98 (0.9, 0.99) | 0.94 (0.87, 0.98) | 0.93 (0.91, 0.98) | |
| order | 1 (1, 1) | 1 (1, 2) | 2 (1.3, 2) | 1 (1, 1.8) | |
| DRD+ | count | 3 | 159 | 166 | |
| time_stop | 13 (11, 14) | 20 (13, 32) | 20 (12, 32) | ||
| n_trt | 25 (25, 27) | 38 (26, 73) | 34 (25, 71) | ||
| n_control | 18 (16, 24) | 39 (22, 74) | 38 (23, 72) | ||
| post_p | 0.92 (0.9, 0.96) | 1 (0.97, 1) | 1 (0.96, 1) | ||
| order | 2 (1.2, 2) | 2 (1, 3) | 2 (1, 3) | ||
| TEfus+ | count | 1 | 167 | 3 | 1 |
| time_stop | 10 (10, 10) | 15 (10, 31) | 9 (7, 12) | 14 (14, 14) | |
| n_trt | 25 (25, 25) | 34 (26, 85) | 25 (25, 33) | 29 (29, 29) | |
| n_control | 19 (19, 19) | 36 (22, 86) | 29 (20, 31) | 41 (41, 41) | |
| post_p | 0.97 (0.97, 0.97) | 0.99 (0.96, 1) | 0.94 (0.88, 0.96) | 0.99 (0.99, 0.99) | |
| order | 1 (1, 1) | 1 (1, 3) | 1 (1, 1) | 2 (2, 2) |
| signature | var | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|
| all | count | 1 | |||
| time_stop | 4 (4, 4) | ||||
| n_trt | 30 (30, 30) | ||||
| n_control | 22 (22, 22) | ||||
| post_p | 0.14 (0.14, 0.14) | ||||
| order | 1 (1, 1) | ||||
| TP53- & AR- | count | 105 | 122 | 110 | |
| time_stop | 14 (9, 24) | 13 (9, 23) | 13 (9, 21) | ||
| n_trt | 36 (26, 70) | 32 (26, 67) | 32 (25, 61) | ||
| n_control | 37 (23, 71) | 34 (21, 73) | 32 (20, 59) | ||
| post_p | 0.04 (0, 0.17) | 0.07 (0.01, 0.24) | 0.06 (0.01, 0.24) | ||
| order | 1 (1, 2) | 1 (1, 2) | 1 (1, 2) | ||
| TP53+ | count | 254 | 3 | 3 | |
| time_stop | 18 (10, 32) | 13 (12, 15) | 11 (9, 13) | ||
| n_trt | 56 (28, 99) | 39 (39, 41) | 38 (29, 39) | ||
| n_control | 54 (25, 99) | 43 (39, 47) | 31 (29, 33) | ||
| post_p | 0.02 (0, 0.13) | 0.03 (0.03, 0.11) | 0.06 (0.06, 0.24) | ||
| order | 1 (1, 3) | 2 (1.2, 2) | 1 (1, 1.8) | ||
| DRD+ | count | 75 | 7 | ||
| time_stop | 20 (14, 32) | 18 (16, 33) | |||
| n_trt | 33 (26, 51) | 33 (30, 84) | |||
| n_control | 40 (23, 62) | 35 (26, 73) | |||
| post_p | 0.03 (0, 0.13) | 0.07 (0.03, 0.13) | |||
| order | 2 (1, 3) | 2 (1, 3) | |||
| TEfus+ | count | 93 | 6 | 11 | |
| time_stop | 22 (11, 35) | 12 (12, 28) | 19 (10, 25) | ||
| n_trt | 47 (26, 83) | 34 (29, 77) | 39 (25, 54) | ||
| n_control | 54 (24, 102) | 33 (26, 75) | 45 (23, 72) | ||
| post_p | 0.01 (0, 0.06) | 0.02 (0, 0.09) | 0.04 (0.02, 0.09) | ||
| order | 2 (1, 3.8) | 3 (1.5, 3) | 2 (1, 4) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
| time | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | ||
| n | 8 (6, 10) | 1 (0, 1) | 4 (3, 5) | 3 (2, 3) | 1 (0, 1) | 4 (2, 5) | 0 (0, 2) | 0 (0, 2) | 1 (0, 3) | 1 (1, 3) | 0 (0, 0) | 0 (0, 1) | 1 (0, 2) | 1 (0, 3) | 1 (1, 1) | 0 (0, 1) | ||
| post_p | 0.73 (0.68, 0.74) | 0.5 (0.5, 0.5) | 0.67 (0.6, 0.73) | 0.6 (0.57, 0.66) | 0.57 (0.54, 0.59) | 0.52 (0.52, 0.52) | 0.5 (0.5, 0.5) | 0.58 (0.58, 0.58) | 0.52 (0.52, 0.52) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.61 (0.61, 0.61) | 0.64 (0.64, 0.64) | 0.56 (0.56, 0.56) | NA (NA, NA) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0 (0, 0.073) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.059 (0.012, 0.106) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0.051 (0.01, 0.092) | 0 (0, 1.248) | 0.291 (0.291, 0.291) | ||
| Niraparib | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| time | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | ||
| n | 8 (8, 8) | 1 (1, 1) | 4 (4, 4) | 2 (2, 2) | 2 (2, 2) | 2 (2, 2) | 2 (2, 2) | 2 (2, 2) | 2 (2, 2) | 1 (1, 1) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 2 (2, 2) | 2 (2, 2) | 2 (2, 2) | ||
| post_p | 0.67 (0.67, 0.67) | 0.68 (0.68, 0.68) | 0.57 (0.57, 0.57) | 0.58 (0.58, 0.58) | 0.55 (0.55, 0.55) | 0.5 (0.5, 0.5) | 0.52 (0.52, 0.52) | 0.52 (0.52, 0.52) | 0.6 (0.6, 0.6) | 0.61 (0.61, 0.61) | 0.6 (0.6, 0.6) | NA (NA, NA) | NA (NA, NA) | 0.52 (0.52, 0.52) | 0.53 (0.53, 0.53) | 0.64 (0.64, 0.64) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.078 (0.078, 0.078) | 0 (0, 0) | 0.085 (0.085, 0.085) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| Taxel_therapies | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |
| time | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | ||
| n | 9 (7, 11) | 2 (0, 2) | 2 (1, 4) | 3 (3, 4) | 2 (2, 3) | 0 (0, 2) | 0 (0, 0) | 1 (0, 1) | 2 (0, 3) | 1 (0, 2) | 2 (1, 3) | 1 (0, 3) | 0 (0, 1) | 0 (0, 3) | 0 (0, 1) | 0 (0, 1) | ||
| post_p | 0.65 (0.62, 0.71) | 0.56 (0.56, 0.56) | 0.63 (0.6, 0.65) | 0.68 (0.68, 0.7) | 0.56 (0.54, 0.59) | 0.6 (0.6, 0.6) | NA (NA, NA) | 0.53 (0.53, 0.53) | 0.8 (0.76, 0.84) | 0.61 (0.61, 0.61) | 0.67 (0.63, 0.73) | 0.55 (0.55, 0.55) | 0.55 (0.55, 0.55) | 0.69 (0.69, 0.69) | 0.51 (0.51, 0.51) | 0.57 (0.57, 0.57) | ||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.075 (0.049, 0.099) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| DRD+ | Carboplatin | count | 166 | 166 | 166 | 166 | 166 | 166 | 166 | 166 | ||||||||
| time | 20 (12, 32) | 20 (12, 32) | 20 (12, 32) | 20 (12, 32) | 20 (12, 32) | 20 (12, 32) | 20 (12, 32) | 20 (12, 32) | ||||||||||
| n | 6 (3, 14) | 5 (3, 15) | 4 (2, 8) | 4 (1, 9) | 4 (1, 9) | 4 (1, 8) | 4 (2, 8) | 4 (2, 8) | ||||||||||
| post_p | 0.76 (0.58, 0.93) | 0.71 (0.53, 0.83) | 0.78 (0.57, 0.96) | 0.71 (0.53, 0.88) | 0.79 (0.58, 0.96) | 0.7 (0.56, 0.88) | 0.78 (0.59, 0.96) | 0.72 (0.53, 0.87) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.028 (0, 0.061) | 0.021 (0, 0.044) | 0.025 (0, 0.066) | 0.023 (0, 0.058) | 0.025 (0, 0.068) | 0.019 (0, 0.056) | 0.034 (0, 0.076) | 0.024 (0, 0.066) | ||||||||||
| Niraparib | count | 159 | 159 | 159 | 159 | 159 | 159 | 159 | 159 | |||||||||
| time | 20 (13, 32) | 20 (13, 32) | 20 (13, 32) | 20 (13, 32) | 20 (13, 32) | 20 (13, 32) | 20 (13, 32) | 20 (13, 32) | ||||||||||
| n | 7 (3, 14) | 7 (3, 16) | 4 (1, 8) | 4 (1, 9) | 4 (2, 8) | 4 (1, 8) | 5 (1, 8) | 4 (2, 8) | ||||||||||
| post_p | 0.76 (0.57, 0.93) | 0.73 (0.53, 0.87) | 0.78 (0.55, 0.96) | 0.72 (0.53, 0.89) | 0.77 (0.57, 0.94) | 0.71 (0.54, 0.9) | 0.8 (0.58, 0.96) | 0.72 (0.53, 0.92) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.029 (0, 0.057) | 0.022 (0, 0.041) | 0.03 (0, 0.068) | 0.022 (0, 0.069) | 0.031 (0, 0.076) | 0.024 (0, 0.058) | 0.029 (0, 0.064) | 0.024 (0, 0.055) | ||||||||||
| Taxel_therapies | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |||||||||
| time | 13 (11, 14) | 13 (11, 14) | 13 (11, 14) | 13 (11, 14) | 13 (11, 14) | 13 (11, 14) | 13 (11, 14) | 13 (11, 14) | ||||||||||
| n | 4 (4, 5) | 5 (4, 5) | 4 (2, 5) | 4 (3, 6) | 1 (0, 3) | 3 (2, 4) | 1 (0, 1) | 3 (2, 5) | ||||||||||
| post_p | 0.54 (0.52, 0.55) | 0.59 (0.55, 0.68) | 0.61 (0.58, 0.67) | 0.73 (0.65, 0.79) | 0.64 (0.63, 0.64) | 0.63 (0.57, 0.65) | 0.56 (0.53, 0.58) | 0.71 (0.67, 0.71) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.075 (0.058, 0.077) | 0 (0, 0.024) | 0.044 (0.009, 0.106) | 0.043 (0.009, 0.054) | 0.029 (0.006, 0.053) | 0 (0, 0.081) | 0 (0, 0) | 0 (0, 0.044) | ||||||||||
| TEfus+ | Carboplatin | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
| time | 14 (14, 14) | 14 (14, 14) | 14 (14, 14) | 14 (14, 14) | 14 (14, 14) | 14 (14, 14) | 14 (14, 14) | 14 (14, 14) | ||||||||||
| n | 3 (3, 3) | 5 (5, 5) | 5 (5, 5) | 3 (3, 3) | 5 (5, 5) | 1 (1, 1) | 3 (3, 3) | 4 (4, 4) | ||||||||||
| post_p | 0.73 (0.73, 0.73) | 0.65 (0.65, 0.65) | 0.78 (0.78, 0.78) | 0.66 (0.66, 0.66) | 0.51 (0.51, 0.51) | 0.69 (0.69, 0.69) | 0.89 (0.89, 0.89) | 0.75 (0.75, 0.75) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0 (0, 0) | 0.053 (0.053, 0.053) | 0 (0, 0) | 0 (0, 0) | 0.158 (0.158, 0.158) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| Hormone_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | ||||||||||
| n | 3 (3, 3) | 5 (5, 5) | 8 (8, 8) | 1 (1, 1) | 4 (4, 4) | 4 (4, 4) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| post_p | 0.69 (0.69, 0.69) | 0.77 (0.77, 0.77) | 0.74 (0.74, 0.74) | 0.54 (0.54, 0.54) | 0.89 (0.89, 0.89) | 0.66 (0.66, 0.66) | NA (NA, NA) | NA (NA, NA) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0 (0, 0) | 0.043 (0.043, 0.043) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.078 (0.078, 0.078) | NA (NA, NA) | NA (NA, NA) | ||||||||||
| Niraparib | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |||||||||
| time | 9 (7, 12) | 9 (7, 12) | 9 (7, 12) | 9 (7, 12) | 9 (7, 12) | 9 (7, 12) | 9 (7, 12) | 9 (7, 12) | ||||||||||
| n | 2 (1, 4) | 11 (9, 13) | 4 (3, 5) | 2 (1, 3) | 2 (1, 3) | 3 (1, 4) | 2 (2, 3) | 2 (2, 3) | ||||||||||
| post_p | 0.52 (0.51, 0.56) | 0.75 (0.72, 0.78) | 0.7 (0.61, 0.75) | 0.57 (0.56, 0.63) | 0.6 (0.57, 0.68) | 0.62 (0.53, 0.7) | 0.54 (0.52, 0.83) | 0.54 (0.53, 0.62) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0 (0, 0.093) | 0.082 (0.041, 0.107) | 0 (0, 0) | 0 (0, 0) | 0.093 (0.019, 0.122) | 0.031 (0.006, 0.055) | 0 (0, 0.03) | 0 (0, 0.069) | ||||||||||
| Taxel_therapies | count | 167 | 167 | 167 | 167 | 167 | 167 | 167 | 167 | |||||||||
| time | 15 (10, 31) | 15 (10, 31) | 15 (10, 31) | 15 (10, 31) | 15 (10, 31) | 15 (10, 31) | 15 (10, 31) | 15 (10, 31) | ||||||||||
| n | 5 (2, 13) | 10 (5, 22) | 5 (2, 12) | 3 (1, 9) | 4 (1, 9) | 4 (2, 10) | 3 (1, 7) | 3 (1, 8) | ||||||||||
| post_p | 0.75 (0.57, 0.9) | 0.9 (0.73, 0.99) | 0.69 (0.53, 0.83) | 0.67 (0.52, 0.86) | 0.78 (0.6, 0.97) | 0.77 (0.57, 0.97) | 0.66 (0.53, 0.83) | 0.68 (0.52, 0.88) | ||||||||||
| r_prob | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.026 (0, 0.061) | 0.037 (0, 0.069) | 0.013 (0, 0.042) | 0.008 (0, 0.064) | 0.025 (0, 0.08) | 0.028 (0, 0.076) | 0.017 (0, 0.061) | 0.019 (0, 0.063) | ||||||||||
| TP53- & AR- | Carboplatin | count | 2 | 2 | 2 | 2 | ||||||||||||
| time | 9 (8, 10) | 9 (8, 10) | 9 (8, 10) | 9 (8, 10) | ||||||||||||||
| n | 16 (15, 18) | 2 (1, 4) | 3 (3, 3) | 4 (3, 6) | ||||||||||||||
| post_p | 0.81 (0.76, 0.86) | 0.63 (0.57, 0.69) | 0.61 (0.55, 0.67) | 0.78 (0.78, 0.79) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.065 (0.04, 0.09) | 0.024 (0.005, 0.043) | 0.062 (0.012, 0.112) | 0 (0, 0) | ||||||||||||||
| Hormone_therapies | count | 272 | 272 | 272 | 272 | |||||||||||||
| time | 12 (9, 28) | 12 (9, 28) | 12 (9, 28) | 12 (9, 28) | ||||||||||||||
| n | 21 (15, 51) | 4 (2, 10) | 4 (2, 11) | 4 (1, 11) | ||||||||||||||
| post_p | 0.96 (0.82, 1) | 0.71 (0.54, 0.87) | 0.71 (0.54, 0.86) | 0.63 (0.52, 0.78) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.039 (0.017, 0.062) | 0.027 (0, 0.076) | 0.017 (0, 0.064) | 0 (0, 0.053) | ||||||||||||||
| Niraparib | count | 2 | 2 | 2 | 2 | |||||||||||||
| time | 12 (12, 13) | 12 (12, 13) | 12 (12, 13) | 12 (12, 13) | ||||||||||||||
| n | 26 (21, 30) | 2 (1, 4) | 5 (5, 5) | 5 (4, 6) | ||||||||||||||
| post_p | 0.78 (0.77, 0.79) | 0.54 (0.53, 0.55) | 0.87 (0.82, 0.91) | 0.72 (0.57, 0.87) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.092 (0.076, 0.108) | 0.045 (0.009, 0.081) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| Taxel_therapies | count | 5 | 5 | 5 | 5 | |||||||||||||
| time | 11 (8, 12) | 11 (8, 12) | 11 (8, 12) | 11 (8, 12) | ||||||||||||||
| n | 22 (17, 25) | 4 (3, 6) | 2 (0, 3) | 1 (0, 4) | ||||||||||||||
| post_p | 0.76 (0.72, 0.8) | 0.75 (0.68, 0.87) | 0.57 (0.54, 0.66) | 0.67 (0.57, 0.75) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.072 (0.059, 0.102) | 0 (0, 0.072) | 0 (0, 0.027) | 0 (0, 0) | ||||||||||||||
| TP53+ | Carboplatin | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||||||
| time | 11 (9, 18) | 11 (9, 18) | 11 (9, 18) | 11 (9, 18) | 11 (9, 18) | 11 (9, 18) | 11 (9, 18) | 11 (9, 18) | ||||||||||
| n | 14 (7, 16) | 4 (3, 5) | 3 (2, 3) | 1 (0, 6) | 3 (2, 5) | 1 (0, 3) | 3 (1, 5) | 5 (3, 5) | ||||||||||
| post_p | 0.85 (0.57, 0.88) | 0.69 (0.62, 0.74) | 0.7 (0.56, 0.72) | 0.69 (0.6, 0.78) | 0.61 (0.58, 0.64) | 0.56 (0.55, 0.57) | 0.68 (0.55, 0.86) | 0.72 (0.68, 0.8) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.136 (0.123, 0.142) | 0 (0, 0.066) | 0 (0, 0.047) | 0 (0, 0) | 0.067 (0.013, 0.145) | 0.035 (0.007, 0.063) | 0 (0, 0.03) | 0 (0, 0.016) | ||||||||||
| Hormone_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | ||||||||||
| n | 6 (6, 6) | 6 (6, 6) | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | 2 (2, 2) | 7 (7, 7) | ||||||||||
| post_p | 0.87 (0.87, 0.87) | 0.76 (0.76, 0.76) | 0.53 (0.53, 0.53) | NA (NA, NA) | 0.51 (0.51, 0.51) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.08 (0.08, 0.08) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 1.02 (1.02, 1.02) | 0.167 (0.167, 0.167) | 0.055 (0.055, 0.055) | ||||||||||
| Niraparib | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |||||||||
| time | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | ||||||||||
| n | 12 (11, 14) | 8 (5, 10) | 2 (1, 4) | 2 (1, 4) | 2 (0, 4) | 2 (2, 4) | 2 (1, 3) | 2 (1, 4) | ||||||||||
| post_p | 0.76 (0.74, 0.85) | 0.72 (0.66, 0.73) | 0.7 (0.56, 0.79) | 0.57 (0.5, 0.68) | 0.6 (0.52, 0.67) | 0.68 (0.57, 0.77) | 0.74 (0.58, 0.86) | 0.56 (0.53, 0.68) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.105 (0.078, 0.131) | 0.08 (0.057, 0.126) | 0.029 (0, 0.06) | 0 (0, 0.025) | 0.122 (0.076, 0.168) | 0.056 (0.016, 0.065) | 0 (0, 0) | 0.027 (0.005, 0.033) | ||||||||||
| Taxel_therapies | count | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | |||||||||
| time | 11 (8, 16) | 11 (8, 16) | 11 (8, 16) | 11 (8, 16) | 11 (8, 16) | 11 (8, 16) | 11 (8, 16) | 11 (8, 16) | ||||||||||
| n | 10 (6, 18) | 8 (5, 12) | 2 (1, 3) | 3 (1, 5) | 3 (1, 4) | 3 (1, 7) | 2 (0, 3) | 2 (0, 5) | ||||||||||
| post_p | 0.78 (0.71, 0.9) | 0.83 (0.73, 0.93) | 0.58 (0.51, 0.7) | 0.68 (0.52, 0.76) | 0.64 (0.55, 0.83) | 0.72 (0.57, 0.85) | 0.53 (0.5, 0.7) | 0.54 (0.52, 0.59) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.101 (0.08, 0.149) | 0.034 (0, 0.057) | 0.025 (0, 0.166) | 0 (0, 0.073) | 0.091 (0.046, 0.125) | 0.01 (0, 0.068) | 0 (0, 0.101) | 0 (0, 0.068) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| time | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | ||
| n | 6 (6, 6) | 1 (1, 1) | 2 (2, 2) | 4 (4, 4) | 0 (0, 0) | 2 (2, 2) | 1 (1, 1) | 2 (2, 2) | 3 (3, 3) | 4 (4, 4) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 2 (2, 2) | 2 (2, 2) | ||
| post_p | 0.44 (0.44, 0.44) | 0.46 (0.46, 0.46) | 0.35 (0.35, 0.35) | NA (NA, NA) | NA (NA, NA) | 0.25 (0.25, 0.25) | NA (NA, NA) | 0.37 (0.37, 0.37) | NA (NA, NA) | NA (NA, NA) | 0.28 (0.28, 0.28) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.36 (0.36, 0.36) | NA (NA, NA) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.182 (0.182, 0.182) | 0 (0, 0) | 0.327 (0.327, 0.327) | 0 (0, 0) | NA (NA, NA) | 0.194 (0.194, 0.194) | 0 (0, 0) | 0.246 (0.246, 0.246) | 0.348 (0.348, 0.348) | 0 (0, 0) | 3.745 (3.745, 3.745) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.274 (0.274, 0.274) | 0.489 (0.489, 0.489) | ||
| DRD+ | count | 75 | 75 | 75 | 75 | 75 | 75 | 75 | 75 | |||||||||
| time | 20 (14, 32) | 20 (14, 32) | 20 (14, 32) | 20 (14, 32) | 20 (14, 32) | 20 (14, 32) | 20 (14, 32) | 20 (14, 32) | ||||||||||
| n | 5 (2, 10) | 5 (2, 12) | 4 (2, 7) | 4 (1, 7) | 4 (1, 8) | 4 (1, 9) | 4 (1, 7) | 3 (1, 8) | ||||||||||
| post_p | 0.4 (0.21, 0.49) | 0.37 (0.18, 0.48) | 0.3 (0.15, 0.47) | 0.21 (0.07, 0.36) | 0.29 (0.13, 0.48) | 0.27 (0.08, 0.45) | 0.3 (0.09, 0.44) | 0.25 (0.07, 0.45) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.086 (0.056, 0.146) | 0.057 (0.036, 0.117) | 0.2 (0.114, 0.413) | 0.173 (0.093, 0.72) | 0.183 (0.113, 0.393) | 0.147 (0.081, 0.38) | 0.199 (0.087, 0.406) | 0.182 (0.078, 0.45) | ||||||||||
| Taxel_therapies | count | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | |||||||||
| time | 18 (16, 33) | 18 (16, 33) | 18 (16, 33) | 18 (16, 33) | 18 (16, 33) | 18 (16, 33) | 18 (16, 33) | 18 (16, 33) | ||||||||||
| n | 6 (5, 17) | 8 (7, 17) | 2 (1, 9) | 5 (2, 10) | 5 (4, 10) | 3 (0, 6) | 6 (4, 8) | 4 (1, 8) | ||||||||||
| post_p | 0.17 (0.05, 0.38) | 0.38 (0.28, 0.42) | 0.29 (0.18, 0.4) | 0.39 (0.22, 0.47) | 0.15 (0.09, 0.27) | 0.34 (0.25, 0.36) | 0.39 (0.26, 0.47) | 0.36 (0.2, 0.44) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.118 (0.069, 0.204) | 0.049 (0.045, 0.083) | 0.191 (0.161, 1.214) | 0.078 (0.058, 0.323) | 0.194 (0.153, 0.424) | 0.125 (0.062, 1.455) | 0.131 (0.116, 0.18) | 0.105 (0.04, 0.159) | ||||||||||
| TEfus+ | Carboplatin | count | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | ||||||||
| time | 12 (12, 28) | 12 (12, 28) | 12 (12, 28) | 12 (12, 28) | 12 (12, 28) | 12 (12, 28) | 12 (12, 28) | 12 (12, 28) | ||||||||||
| n | 5 (4, 11) | 7 (5, 21) | 5 (4, 12) | 4 (2, 5) | 6 (2, 10) | 6 (2, 10) | 2 (0, 8) | 2 (1, 4) | ||||||||||
| post_p | 0.22 (0.1, 0.36) | 0.26 (0.06, 0.39) | 0.36 (0.21, 0.46) | 0.38 (0.3, 0.42) | 0.27 (0.1, 0.43) | 0.25 (0.12, 0.31) | 0.36 (0.18, 0.41) | 0.45 (0.24, 0.48) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.19 (0.119, 0.566) | 0.167 (0.147, 0.291) | 0.056 (0.039, 0.078) | 0.071 (0.038, 0.087) | 0.21 (0.17, 0.334) | 0.182 (0.153, 0.517) | 0.143 (0.076, 0.537) | 0.067 (0.025, 0.332) | ||||||||||
| Hormone_therapies | count | 93 | 93 | 93 | 93 | 93 | 93 | 93 | 93 | |||||||||
| time | 22 (11, 35) | 22 (11, 35) | 22 (11, 35) | 22 (11, 35) | 22 (11, 35) | 22 (11, 35) | 22 (11, 35) | 22 (11, 35) | ||||||||||
| n | 5 (2, 12) | 12 (6, 24) | 5 (2, 12) | 4 (1, 9) | 6 (3, 10) | 5 (2, 10) | 4 (2, 9) | 4 (2, 9) | ||||||||||
| post_p | 0.42 (0.29, 0.49) | 0.21 (0.04, 0.39) | 0.39 (0.18, 0.49) | 0.24 (0.07, 0.4) | 0.29 (0.08, 0.47) | 0.3 (0.09, 0.44) | 0.24 (0.07, 0.45) | 0.23 (0.06, 0.43) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.086 (0.055, 0.154) | 0.163 (0.117, 0.238) | 0.06 (0.032, 0.129) | 0.168 (0.08, 0.43) | 0.181 (0.104, 0.445) | 0.185 (0.1, 0.398) | 0.167 (0.073, 0.412) | 0.146 (0.079, 0.489) | ||||||||||
| Niraparib | count | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | |||||||||
| time | 19 (10, 25) | 19 (10, 25) | 19 (10, 25) | 19 (10, 25) | 19 (10, 25) | 19 (10, 25) | 19 (10, 25) | 19 (10, 25) | ||||||||||
| n | 5 (2, 7) | 12 (7, 21) | 5 (0, 9) | 2 (0, 4) | 6 (4, 10) | 4 (3, 5) | 2 (0, 7) | 2 (1, 8) | ||||||||||
| post_p | 0.25 (0.05, 0.4) | 0.21 (0.11, 0.43) | 0.39 (0.24, 0.48) | 0.41 (0.28, 0.5) | 0.32 (0.24, 0.42) | 0.34 (0.24, 0.45) | 0.46 (0.44, 0.49) | 0.35 (0.27, 0.45) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.189 (0.127, 0.526) | 0.171 (0.113, 0.262) | 0.067 (0.027, 0.084) | 0.103 (0.042, 0.24) | 0.18 (0.134, 0.397) | 0.179 (0.115, 0.328) | 0.071 (0.029, 0.918) | 0.111 (0.077, 0.239) | ||||||||||
| TP53- & AR- | Carboplatin | count | 122 | 122 | 122 | 122 | ||||||||||||
| time | 13 (9, 23) | 13 (9, 23) | 13 (9, 23) | 13 (9, 23) | ||||||||||||||
| n | 22 (15, 43) | 4 (2, 10) | 4 (2, 9) | 5 (2, 9) | ||||||||||||||
| post_p | 0.13 (0.01, 0.36) | 0.28 (0.06, 0.46) | 0.45 (0.34, 0.49) | 0.4 (0.23, 0.49) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.161 (0.121, 0.212) | 0.164 (0.071, 0.384) | 0.083 (0.042, 0.195) | 0.06 (0.026, 0.147) | ||||||||||||||
| Niraparib | count | 110 | 110 | 110 | 110 | |||||||||||||
| time | 13 (9, 21) | 13 (9, 21) | 13 (9, 21) | 13 (9, 21) | ||||||||||||||
| n | 21 (15, 38) | 5 (2, 9) | 4 (1, 9) | 4 (2, 9) | ||||||||||||||
| post_p | 0.16 (0.02, 0.43) | 0.26 (0.05, 0.45) | 0.42 (0.26, 0.49) | 0.4 (0.25, 0.49) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.152 (0.116, 0.208) | 0.167 (0.087, 0.396) | 0.082 (0.047, 0.182) | 0.063 (0.022, 0.207) | ||||||||||||||
| Taxel_therapies | count | 105 | 105 | 105 | 105 | |||||||||||||
| time | 14 (9, 24) | 14 (9, 24) | 14 (9, 24) | 14 (9, 24) | ||||||||||||||
| n | 24 (15, 42) | 4 (1, 8) | 5 (2, 10) | 5 (2, 10) | ||||||||||||||
| post_p | 0.09 (0, 0.33) | 0.45 (0.34, 0.49) | 0.25 (0.05, 0.44) | 0.4 (0.24, 0.48) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.156 (0.123, 0.224) | 0.095 (0.045, 0.213) | 0.155 (0.085, 0.315) | 0.058 (0.03, 0.146) | ||||||||||||||
| TP53+ | Carboplatin | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||||||
| time | 13 (12, 15) | 13 (12, 15) | 13 (12, 15) | 13 (12, 15) | 13 (12, 15) | 13 (12, 15) | 13 (12, 15) | 13 (12, 15) | ||||||||||
| n | 13 (12, 22) | 5 (4, 11) | 0 (0, 2) | 2 (2, 4) | 4 (2, 6) | 4 (4, 6) | 1 (0, 1) | 3 (1, 5) | ||||||||||
| post_p | 0.28 (0.1, 0.28) | 0.2 (0.11, 0.23) | 0.46 (0.46, 0.46) | 0.48 (0.35, 0.49) | 0.39 (0.16, 0.39) | 0.25 (0.19, 0.31) | 0.44 (0.39, 0.49) | 0.47 (0.46, 0.47) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.168 (0.155, 0.328) | 0.192 (0.158, 0.232) | 0.13 (0.13, 0.13) | 0.027 (0.005, 0.072) | 0.374 (0.246, 0.516) | 0.221 (0.183, 0.316) | 0.082 (0.016, 0.147) | 0.049 (0.01, 0.058) | ||||||||||
| Hormone_therapies | count | 254 | 254 | 254 | 254 | 254 | 254 | 254 | 254 | |||||||||
| time | 18 (10, 32) | 18 (10, 32) | 18 (10, 32) | 18 (10, 32) | 18 (10, 32) | 18 (10, 32) | 18 (10, 32) | 18 (10, 32) | ||||||||||
| n | 18 (8, 35) | 11 (6, 23) | 4 (1, 8) | 4 (1, 8) | 5 (1, 10) | 5 (2, 10) | 4 (1, 8) | 4 (1, 8) | ||||||||||
| post_p | 0.34 (0.1, 0.48) | 0.19 (0.03, 0.42) | 0.33 (0.12, 0.48) | 0.24 (0.08, 0.45) | 0.37 (0.19, 0.48) | 0.33 (0.12, 0.47) | 0.27 (0.09, 0.46) | 0.25 (0.07, 0.43) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.178 (0.14, 0.263) | 0.163 (0.113, 0.266) | 0.174 (0.101, 0.434) | 0.165 (0.076, 0.466) | 0.201 (0.138, 0.443) | 0.175 (0.098, 0.376) | 0.19 (0.097, 0.467) | 0.178 (0.086, 0.435) | ||||||||||
| Niraparib | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |||||||||
| time | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | ||||||||||
| n | 10 (9, 15) | 10 (8, 12) | 2 (0, 3) | 3 (2, 4) | 2 (2, 3) | 3 (1, 5) | 1 (0, 1) | 3 (1, 4) | ||||||||||
| post_p | 0.4 (0.19, 0.45) | 0.21 (0.11, 0.32) | 0.44 (0.4, 0.48) | 0.28 (0.25, 0.4) | 0.37 (0.36, 0.39) | 0.41 (0.34, 0.44) | 0.48 (0.46, 0.49) | 0.42 (0.42, 0.43) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.199 (0.159, 0.262) | 0.188 (0.18, 0.214) | 0.077 (0.049, 0.104) | 0.178 (0.134, 0.245) | 0.164 (0.144, 0.268) | 0.125 (0.124, 0.336) | 0.11 (0.022, 0.198) | 0.085 (0.078, 0.093) |